ARID1A

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ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
She said the PhilHealth's 2014 annual report figure of maximum benefit at P270,000 per dialysis patient reflects only 46.
Manila: A 46-year-old housewife from Metro Manila's Las Pinas placed a bet on the ATM number of her husband and hit the P270 million (Dh22.
These belong respectively to the 27-metre and 90-tonne P270 and 35-metre and 140-tonne P350 models of aluminium craft, which in different versions have been sold to national and Mediterranean customers, including Libya, Croatia, Slovenia, Tunisia and Romania.
stainless steel, 10 |xm, Waters); preparative HPLC was performed on a Elite P270 preparative HPLC system equipped Preparative [C.
The P270 is the first device on the market that combines UMA and 3G network technology.
Argonne and Maxwell have agreed on an active parallel system configuration that will combine a standard lithium-ion plug-in hybrid battery with a string of 112 of Maxwell's BOOSTCAP BCAP0650 P270 650-farad ultracapacitor cells, along with appropriate power electronics and cooling and safety-related features.
Earnings of PCPPI fell by half to P136 million in the first quarter from P270 million a year ago on intense price competition, higher spending and the impact of the damage caused by Typhoon Yolanda.
Best Mobile Handset - 3G Phone: Finalists are LG Electronics KF-757, Samsung P270, and Sony Ericsson G705u
Task 4: The contract is for the purchase and supply of brand new spare parts for vehicle chassis SCANIA P94, SCANIA P270, P280 SCANIA, SCANIA 9B280, SCANIA R420.
Argonne and Maxwell have agreed on an active parallel system configuration that will combine a standard lithium-ion plug-in hybrid battery with a string of 112 of Maxwell's BOOSTCAP(R) BCAP0650 P270 650-farad ultracapacitor cells, along with appropriate power electronics and cooling and safety-related features.
15 billion and operating income doubling to P554 million from P270 million as a result of focused marketing and selling initiatives, price increases and more effective cost control.