CDKN2A

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CDKN2A

A gene on chromosome 9p21 that encodes an alternate open reading frame (ARF) product, which acts as a tumour suppressor by binding to MDM2 and blocking its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits MDM2’s oncogenic activity, which would normally degrade p53, a tumour suppressor protein. CDKN2A also induces G2 arrest and apoptosis, independent of p53, by preventing the activation of cyclin B1/CDC2 complexes.

CDKN2A also binds to:
• BCL6, downregulating BCL6-induced transcriptional repression;
• E2F1 and MYC, blocking their transcriptional activator activity;
• HUWE1, repressing its ubiquitin ligase activity;
• TOP1/TOPOI, stimulating its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.

CDKN2A interacts with:
• COMMD1 and promotes its “Lys63”-linked polyubiquitination;
• NPM1/B23, promoting its polyubiquitination and degradation and inhibiting rRNA processing;
• UBE2I/UBC9, enhacing sumoylation of some of its binding partners (e.g., MDM2 and E2F1).
References in periodicals archive ?
The regulations set the submission deadline for P14 and P35 as May 19.
Boiler P13 and Boiler P14 are placed in heating plant 2 (VEnrmeverk 2) are two EO5 fired boile.
UNITED MANAGERS - HOW THEY STARTED TOMMY DOCHERTY Appointed December 1972 P14 W5 D5 L4 DAVE SEXTON Appointed summer 1977 P14 W5 D2 L7 RON ATKINSON Appointed summer 1981 P14 W7 D5 L2 SIR ALEX FERGUSON Appointed November 1986 P14 W6 D5 L3
The P14 model, to be marketed under the Cogenix brand, features a "C" frame design, providing safe and easy access for the operator when loading and removing samples from between the heated platens, according to the company.
Revenues of the Packaging division rose 16% to P14.
Tenders are invited for Special Repairs To Building P14 At Ins Virbahu Under Ge Nb Visakhapatnam
There are regular services to the Arena on five main routes: D1, D6, D8, 277 and P14.
As the farmgate cost of unmilled rice have started declining to P14 to P16 per kilogram in several areas, the National Food Authority (NFA) has announced its plans of intensifying the procurement of palay or unhusked rice in 2015.
for comparison purposes, these results represent an increase of 3% in net sales from P14.
The offer comprises a 43 percent premium over Indophil's closing price at the ASX yesterday, and values the Australian company at A$361 million, or approximately P14.