CDKN2A

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CDKN2A

A gene on chromosome 9p21 that encodes an alternate open reading frame (ARF) product, which acts as a tumour suppressor by binding to MDM2 and blocking its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits MDM2’s oncogenic activity, which would normally degrade p53, a tumour suppressor protein. CDKN2A also induces G2 arrest and apoptosis, independent of p53, by preventing the activation of cyclin B1/CDC2 complexes.

CDKN2A also binds to:
• BCL6, downregulating BCL6-induced transcriptional repression;
• E2F1 and MYC, blocking their transcriptional activator activity;
• HUWE1, repressing its ubiquitin ligase activity;
• TOP1/TOPOI, stimulating its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation.

CDKN2A interacts with:
• COMMD1 and promotes its “Lys63”-linked polyubiquitination;
• NPM1/B23, promoting its polyubiquitination and degradation and inhibiting rRNA processing;
• UBE2I/UBC9, enhacing sumoylation of some of its binding partners (e.g., MDM2 and E2F1).
References in periodicals archive ?
element-invisibleNation ( Article MRec ), pagematch: 1, sectionmatch: 1"There is no evidence showing that respondent Suplico exerted efforts to ensure that AARON liquidated the P14,700,000 which could only mean that he benefitted from the transaction or that he was grossly negligent," the ombudsman's resolution read.
A cartoon of Admiral Lord Nelson will be auctioned off on the festival's closing night at the Philharmonic Hall on July 17Paul Merton interview and full Festival line -up - see 24/7 n Have we got comedians for you: P14 ( Picture: EDDIE BARFORD
But Balutan has disputed Cam's statement, saying the Department of Budget and Management (DBM) had approved the original Christmas party budget of P14 million, but that he had it cut down to P6 million.
The MOA indicates that each victim of super-typhoon Yolanda under the "totally damaged" category will receive the entire P14,286.
Plasticity measurement using the P14 VFF is said to offer a quick, low cost method of characterizing the flow behavior of rubber compounds.
The MOA indicates that victims of super typhoon Yolanda under the "totally damaged" category will receive the entire P14, 286.
The latest Employer's Bulletin announces a tightening in the operation of the deadline for the submission of employers' year-end PAYE and NIC returns, P14 and P35.
The P14 model, marketed under the Cogenix brand, features a c-frame design, providing safe and easy access for the operator when loading and removing samples from between the heated platens, according to the company.
73% fare hike, or from P10 to P14 per kilometer charge to P11 to P15, in addition to the base rate of P40.
LAPU-LAPU CITY, Cebu -- Not a single centavo of the P14.