P-glycoprotein

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glycoprotein

 [gli″ko-pro´tēn]
any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.
α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.
P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.
variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),
Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.
Synonym(s): P-170

P-gly·co·pro·tein

(glī'kō-prō'tēn)
Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.
See also: glycoprotein
References in periodicals archive ?
Cannon and his NIEHS colleagues initially found that amitriptyline significantly reduced P-glycoproteins pump activity in brain capillaries from wild-type rats.
Located along the inner lining of brain blood vessels, P-glycoprotein directs toxins and pharmaceuticals back into the bodys circulation before they pass into the brain.
The aim of the present investigation was, firstly, to investigate whether or not tumor cells specifically over-expressing ABCB1- and ABCB5-type P-glycoproteins are cross-resistant to (-)-sesamin.
P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance.
Concise guide to drug interaction principles for medical practice: cytochrome P450s, UGTS, p-glycoproteins.
while P-glycoproteins were increased, a condition that limits the absorption of oral drugs.
Another useful effect of this agent is the inhibition of P-glycoproteins by its metabolites (10).
Most cells in the body are low in MDR1, therefore requiring the cells to produce P-glycoproteins which become incorporated into the cell membrane and in the process remove the toxins from the cells.
A certain group of Transport proteins, the P-glycoproteins, have been shown to effect the delivery of some drugs to cancer cells.
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
Most people don't talk about their p-glycoproteins, but everybody's got them.
This resistance is likely the result of multidrug resistance P-glycoproteins and MDR-associated proteins together with reduced hepatocellular drug uptake into the tumors (G Zollner 2005).