P-glycoprotein

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glycoprotein

 [gli″ko-pro´tēn]
any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.
α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.
P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.
variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),
Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.
Synonym(s): P-170

P-gly·co·pro·tein

(glī'kō-prō'tēn)
Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.
See also: glycoprotein
References in periodicals archive ?
The aim of the present investigation was, firstly, to investigate whether or not tumor cells specifically over-expressing ABCB1- and ABCB5-type P-glycoproteins are cross-resistant to (-)-sesamin.
P-glycoprotein (MDR1/ABCB1) is the best known ATP- binding cassette (ABC) drug transporter mediating MDR.
while P-glycoproteins were increased, a condition that limits the absorption of oral drugs.
Another useful effect of this agent is the inhibition of P-glycoproteins by its metabolites (10).
Most cells in the body are low in MDR1, therefore requiring the cells to produce P-glycoproteins which become incorporated into the cell membrane and in the process remove the toxins from the cells.
Werbeloff (2001) explains that phase 1 involves the action of cytochrome P450 and P-glycoprotein which remove toxic substances that if not cleared will often manifest as an external skin condition.
A certain group of Transport proteins, the P-glycoproteins, have been shown to effect the delivery of some drugs to cancer cells.
Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.
The MDR1 gene encodes an integral membrane protein, P-glycoprotein (PGP), whose function is the energy-dependent export of substances from the inside of cells to the outside (3).
Most people don't talk about their p-glycoproteins, but everybody's got them.
now say they have successfully spliced the human p-glycoprotein gene into mouse embryos to make strains of mice whose marrow cells can resist a wide variety of anticancer drugs.
This resistance is likely the result of multidrug resistance P-glycoproteins and MDR-associated proteins together with reduced hepatocellular drug uptake into the tumors (G Zollner 2005).