P-glycoprotein


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Related to P-glycoprotein: ABCB1

glycoprotein

 [gli″ko-pro´tēn]
any of a class of conjugated proteins consisting of a compound of protein with a carbohydrate group.
α1-acid glycoprotein an acute phase protein found in blood plasma, an indicator of tissue necrosis and inflammation. Called also orosomucoid.
P-glycoprotein a cell-surface protein occurring normally in the colon, small intestine, adrenal glands, kidney, and liver, and also expressed by tumor cells. It is a modulator of multidrug resistance, mediating the transport of antineoplastic agents out of tumor cells.
variable surface glycoprotein any of several glycoproteins that form the antigenic protein coating of Trypanosoma brucei. The organisms contain numerous genes encoding hundreds of such glycoproteins and, by expressing individual ones successively, evade the immune system of the host.

P-gly·co·pro·tein

(glī'kō-prō'tēn),
Protein associated with tumor multidrug resistance; acts as energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.
Synonym(s): P-170

P-gly·co·pro·tein

(glī'kō-prō'tēn)
Protein associated with tumor multidrug resistance; acts as an energy-requiring efflux pump for many classes of natural products and chemotherapeutic drugs.

P-glycoprotein

A cell membrane pump that influences cellular uptake and release of chemicals. It affects the relative resistance or susceptibility of cells to drug therapy.
See also: glycoprotein
References in periodicals archive ?
Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.
P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines.
Splenda alters gut microflora and increases intestinal P-glycoprotein and cytochrome P-450 in male rats [abstract.
Polymethoxylated flavones in orange juice are inhibitors of P-glycoprotein but not cytochrome P450 3A4.
Inhibition of p-glycoprotein decreases intestinal and renal clearance of digoxin, the most common example of which is the interaction between digoxin and quinidine.
p-glycoprotein (pgp)) in the intestinal epithelium may affect drug absorption.
Some drugs are ineffective against cancer cells that have certain forms of P-glycoprotein.
The echinocandin caspofungin (Cancidas) has "no significant interaction" with cytochrome P-450 (CYP450) metabolism or P-glycoprotein, according to product labeling.
Although several models have been proposed for P-glycoprotein's action, basically P-glycoprotein acts to move xenobiotics from epithelial cells into the adjacent lumen.
The transporter proteins responsible for MXR include P-glycoprotein (P-gp), multidrug-resistance protein (MRP), and other members of the ABC (ATP-binding cassette) family of transport proteins.
In this study, one of the cell lines expresses mutant tubulin, and the other cell line over-expresses P-glycoprotein (Pgp).