ABCB1
(redirected from P-GP CD243)ABCB1
A gene on chromosome 7p21.12, which encodes an ATP-binding cassette (ABC) transporter superfamily of integral membrane protein. It is an ATP-dependent efflux pump for xenobiotics with broad substrate specificity, and functions as a transporter in the blood-brain barrier.Molecular pathology
The ABCB1 protein product is responsible for reducing drug loads in multi-drug-resistant cells, thereby mediating resistance to anti-cancer drugs.