In a paper published today in the journal Nature Communications, the team describe how inammation triggers the release of powerful molecules - including oxygen free radicals
or reactive oxygen species - which have been linked to ageing.
This then led to less efficient energy production and more release of oxygen free radicals
, toxic by-products of mitochondrial metabolism.
On closer examination, the researchers found that resveratrol mitigated the damage done by oxygen free radicals
, generated by the breakdown of the dopamine, and activated protein signalling pathways that appeared to promote cell survival.
Again, the TLR4-deficient mice produced fewer oxygen free radicals
in response to polluted air than did normal mice.
Oxygen may increase lung injury by providing oxygen free radicals
Oxygen free radicals
in brain dysfunction; International journal of Neuroscience, 57: 1-17.
The most common oxygen free radicals
are the singlet oxygen, the hydroxyl radical, and the superoxide anion, all of which are normally found in your skin because of its high rate of metabolic oxidation and the availability of fatty acids.
The authors conclude that the reduction is due to pixantrone's inability to generate toxic drug iron complexes and reduced propensity to generate oxygen free radicals
Antioxidants mop up dangerous oxygen free radicals
, destructive molecules that damage cell walls and DNA.
In addition, Bagchi discovered that natural astaxanthin is 14 times more potent than alpha-tocopherol, 54 times more potent that beta-carotene and 65 times more potent that ascorbic acid (vitamin C) in scavenging oxygen free radicals
In cells, these by-products are called oxygen free radicals
, also known as reactive oxygen species.
ORAC--or oxygen radical absorbance capacity--is a measure of the ability of foods and other compounds to subdue oxygen free radicals