ovarian hyperstimulation syndrome


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ovarian hyperstimulation syndrome

iatrogenic development of ovarian hyperstimulation that occurs when the luteotropic effects of human chorionic gonadotropin are exaggerated in a cycle in which ovarian stimulation has been done as a component of infertility treatment. The human chorionic gonadotropin is administered exogeneously to trigger ovulation after gonadotropin stimulation. It is present endogenously after implantation. Syndrome includes, to varying degrees, abdominal distention, potentially massive ovarian enlargement, and third spacing of vascular volume. It can range from moderate discomfort to life-threatening ovarian enlargement and fluid shifts.

ovarian hyperstimulation syndrome

,

OHSS

A potentially life-threatening complication that may occur in women receiving drugs to stimulate ovulation. The acute onset occurs within the first week ovulation is induced and is characterized by marked cystic ovarian enlargement, ascites, hydrothorax, arterial hypotension, tachycardia, hemoconcentration, oliguria, sodium retention, hypernatremia, and in severe cases renal failure. The condition is usually mild if the diameter of the ovary is less than 8 cm; moderate if 8 to 12 cm; and severe if greater than 12 cm.

Treatment includes symptomatic therapy to maintain circulatory function, bedrest, a low-sodium diet, and diuretic therapy. The life-threatening possibility can be avoided with close monitoring and withholding of drugs if ovarian response becomes excessive.

ovarian hyperstimulation syndrome

Ovarian enlargement, the production of multiple ovarian cysts, increased capillary permeability with generalized oedema and intravascular fluid depletion, SHOCK, and sometimes even death. The syndrome, which is uncommon, is caused by gonadotropin medical treatment to stimulate ovulation. Rarely, it may occur spontaneously during pregnancy as a result of a mutation in the gene for the follicle-stimulating hormone receptor.
References in periodicals archive ?
Reproductive outcome of fresh or frozen-thawed embryo transfer is similar in high-risk patients for ovarian hyperstimulation syndrome using GnRH agonist for final oocyte maturation and intensive luteal support.
High pregnancy rates and successful prevention of severe ovarian hyperstimulation syndrome by 'prolonged coasting' of very hyperstimulated patients: a multicentre study.
A chorionic gonadotropin-sensitive mutation in the follicle-stimulating hormone receptor as a cause of familial gestational spontaneous ovarian hyperstimulation syndrome.
Ovarian Hyperstimulation Syndrome as an Etiology of Obstructive Uropathy.
Direct correlation between plasma renin activity and severity of ovarian hyperstimulation syndrome.
One of the most serious complications of ART is ovarian hyperstimulation syndrome.
2] concentration is therefore an essential variable for evaluating the progression of stimulation, adjusting daily gonadotropin therapy, predicting the optimal day for induction of ovulation [administration of human chorionic gonadotropin (hCG)] (7), preventing ovarian hyperstimulation syndrome (8, 9), and ensuring that pituitary function is adequately suppressed if a long-acting gonadoliberin-releasing hormone agonist (GnRHa) is used before stimulation (10).
They were so excited about the treatment, after years of trying for a baby, that they were not at all worried as they were told about ovarian hyperstimulation syndrome.
Both authors noted that IVF with frozen embryo transfer has become more common, and that freeze-all protocols in which all embryos are frozen and transferred in a later cycle have emerged to reduce the risk for ovarian hyperstimulation syndrome (OHSS), and to address concerns about endometrial receptivity in women undergoing controlled ovarian stimulation and/or experiencing a premature elevation of progesterone.
Background: The effect of ovarian hyperstimulation syndrome (OHSS) on pregnancy outcomes of in vitro fertilization (IVF) patients is still ambiguous.
INTRODUCTION: Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic systemic disease (1).