estropipate(redirected from Ortho-est)
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estropipate/es·tro·pi·pate/ (es´tro-pĭ-pāt) a compound of estrone sulfate and piperazine; used as an estrogen.
A semisynthetic estrogenic compound, C22H32N2O5S, consisting of the sulfate form of estrone stabilized with piperazine, used in estrogen replacement therapy.
indications It is prescribed in the treatment of vasomotor symptoms of menopause, atrophic vaginitis, kraurosis vulvae, female hypogonadism, female castration, and primary ovarian failure. Estrogens should be used topically whenever possible for treating symptoms of menopause (e.g., vaginal atrophy).
contraindications Should not be used to prevent coronary vascular disease. Known or suspected cancer of the breast or estrogen-dependent neoplasia, pregnancy, thrombophlebitis or thromboembolic disorders, undiagnosed abnormal genital bleeding, or complications of previous administration of estrogen prohibit its use.
adverse effects Among the most serious adverse effects are a possible increased risk of cancer, gallbladder disease, and thromboembolic disorders.
estropipateAn oestrogen drug used for post-menopausal HORMONE REPLACEMENT THERAPY. A brand name is Harmogen.
a preparation of piperazine estrone sulfate used therapeutically for its estrogenic activity.