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coli K-12 that requires pyrimidine in minimal growth medium, due to suboptimal expression ofthe enzyme orotate phospho-ribosyltransferase coded for by the orotate phosphoribosyltransferase (pyrE) gene (16).
In the analysis of urine from patients with orotic acidurias caused by orotate phosphoribosyltransferase (EC 2.
It could be caused by the inhibition of orotate phosphoribosyltransferase by accumulating abnormal metabolites.