original antigenic sin


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original antigenic sin

the observation that a secondary immune response occurs when B lymphocytes are exposed to closely related, but not identical, antigens and that the antibodies formed react more strongly with the antigen that elicited the primary response. Called also the doctrine of original antigenic sin. Noted originally for influenza virus. See also memory cells.
References in periodicals archive ?
However, seroconversion rates for A/New Caledonia (10%) were comparable to those of the more recent A/Brisbane/59/2007(H INI) strain (12%), and thus we could not distinguish original antigenic sin on that basis.
The concept of original antigenic sin is a probable explanation.
Original antigenic sin responses to influenza viruses.
Elsewhere in this issue, Adalja and Henderson propose that original antigenic sin has altered the population age-specific incidence of infection and disease caused by influenza A pandemic (H1N1) 2009 virus and that public health responses must account for the disruption (1).
Later studies by many investigators showed original antigenic sin to be a general phenomenon associated with numerous related/ sequentially infecting virus strains that contain multiple external epitopes of varying cross-specificity (i.
Original antigenic sin seems to be most pronounced when sequential viruses are of intermediate antigenic relatedness; when they are antigenically complex; and when sequential exposure intervals are long, consistent with ongoing selection and expansion of lymphocyte clones that have increasing antibody avidity at key cross-reactive epitopes (7-10) and possibly with epitope competition between naive and antigen-specific B cells (8).
In 1960, Thomas Francis proposed the hypothesis of original antigenic sin, a phenomenon whereby a person who as a child was first exposed to a specific influenza virus A would, throughout life, mount an immune response to the virus of childhood, even when exposed to other antigenically dissimilar influenza viruses.
original antigenic sin was apparent in each age cohort.
Evidence from more recent studies largely supported the veracity of original antigenic sin.
Surely his thoughts about this matter were the genesis of the concepts expressed in On the Doctrine of Original Antigenic Sin, published in 1960 (6).
This we have called the Doctrine of the Original Antigenic Sin.
Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.