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danaparoid
(redirected from Orgaran)

   Also found in: Wikipedia 0.01 sec.
danaparoid /da·nap·a·roid/ (dah-nap´ah-roid) an antithrombotic used as the sodium salt in the prophylaxis of pulmonary thromboembolism and deep venous thrombosis.
danaparoid,
an anticoagulant.
indications It is used to prevent vein thrombosis in hemodialysis, stroke, elective surgery for malignancy or total hip replacement, and hip fracture surgery.
contraindications Hypersensitivity to this drug, sulfites, or pork products prohibits its use. Other factors that contraindicate its use include hemophilia, leukemia with bleeding, thrombocytopenia, purpura, cerebrovascular hemorrhage, cerebral aneurysm, severe hypertension, and other severe cardiac disease.
adverse effects Life-threatening side effects include hemorrhage and thrombocytopenia. Hypersensitivity reactions and rash are additional adverse effects.

danaparoid [dah-nap´ah-roid]
an agent used as the sodium salt in prophylaxis of pulmonary thromboembolism and deep venous thrombosis.

danaparoid
Orgaran® Cardiovascular disease An injectable, LMW heparin that ↓ risk of postop DVT and PE after hip replacement surgery; it is also used for heparin-induced thrombocytopenia. See Deep vein thrombosis, Heparin-induced thrombocytopenia, Pulmonary embolism.


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Common pharmacologicals used in DVT prophylaxis include Innohep, Orgaran and Clexane (New Ethicals Compendium 2004).
FDA cited deficiencies in the conduct of a clinical study entitled: "Trial of Org 10172 in Acute Stroke Treatment (TOAST)," studying Orgaran (danaparoid sodium) injection, sponsored by the National Institutes of Health and Organon.
 
 
 
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