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Ondine's curse

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Ondine's curse
[ondēnz′]
Etymology: L, Undine, mythic water nymph; ME, curs, invocation
apnea caused by loss of automatic control of respiration. The term refers to a syndrome in patients with a defect in central chemoreceptor responsiveness to carbon dioxide. The patient is able to breathe voluntarily but has hypercapnia and hypoxemia. Ondine's curse may result in pickwickian syndrome or sleep apnea and may be one cause of sudden infant death syndrome. The syndrome may occur as a result of opioid or other drug overdose, after bulbar poliomyelitis or encephalitis, or after surgery involving the brainstem or the higher segments of the cervical spinal cord, as in cervical cordotomy for intractable pain.

Ondine's Curse
A popular term for
(1) Primary alveolar (congenital central) hypoventilation (central apnoea)
(2) Sleep apnoea syndrome

Ondine's curse [on´dēnz]
a condition in which patients have lost autonomic control of respiration and become apneic upon falling asleep; it is due to lesions or surgery of the high spinal cord or brainstem; named after Ondine, a water nymph in Greek mythology who caused a mortal who loved her to sleep forever.


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Ondine's Curse may also be possibly related to Hirschsprung's Disease, but the diagnosis of CCHS is so rare that it has an estimated prevalence of one case per 200,000 live births, with only about 300 children living worldwide with CCHS diagnosis.
Curse of sleep CONGENITAL central hypoventilation syndrome (CCHS) is also known as Ondine's Curse, named after a mythological water nymph Ondine who was punished by the gods after falling in love with a knight by being condemned to stay awake in order to breathe.
His breathing difficulties are caused by a syndrome called Ondine's Curse, when the nervous system fails to control breathing while the sufferer is asleep.
 
 
 
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