grape seed extract(redirected from Oligomeric proanthocyanidins)
grape seed extract(grayp seed ex-trakt) ,
Vitis vinifera(trade name),
Vitis coignetiae(trade name),
Oligomeric Proanthocyanidins (OPCs)(trade name)
Chronic venous insufficiency, edema, diabetic retinopathy, varicose veins, cancer prevention, atherosclerosis, cirrhosis, prevention of collagen breakdown, vision problems, constipation, antioxidant, wound healing.
ClassificationTherapeutic: cardioprotective agents
Grape flavonoids have a wide range of effects including antioxidant, vasodilatory, antiplatelet, decreased superoxide production, free-radical removal and inhibition of collagenase.
Reduced risk of coronary disease.
Decreased skin and vasculature breakdown.
Metabolism and Excretion: Unknown.
Contraindicated in: Hypersensitivity or allergy to grape seed extract; Patients with bleeding disorders or receiving anticoagulant therapy.
Use Cautiously in: Obstetric: Avoid use in pregnancy due to lack of safety data.
Adverse Reactions/Side Effects
Central nervous system
- dry skin
Ear, Eye, Nose, Throat
- sore throat
- ↑ risk of bleeding
InteractionsMay ↑ anticoagulant effects of warfarin.May ↓ plasma levels of CYP1A2 substrates.May inhibit the growth of lactobacillus acidophilus.May ↑ BP in hypertensive patients also takingvitamin c.
Oral (Adults) 75–300 mg daily.
- Monitor BP periodically during therapy.
- Lab Test Considerations: Monitor serum cholesterol levels periodically during therapy.
Potential Nursing DiagnosesActivity intolerance (Indications)
- Administer as directed. Doses may vary.
- Advise patient not to take grape seed extract with Vitamin C; may cause increase in BP.
- Advise female patients to notify health care professional if pregnancy is planned or suspected.
- Decrease in cholesterol.
- Decrease in BP.
grape seed extractAbbreviation: GSE
An extract of antioxidant oils isolated from the seeds of grapes (Vitis vinifera) and promoted by alternative and complementary medical practitioners as a potential treatment for coronary artery disease, cancer, and other illnesses produced or worsened by oxidative stresses on body tissues. The extract has been used as a traditional European remedy for diseases of the eyes and skin seems to reduce postoperative swelling faster than placebo. Scientific evidence for its clinical effectiveness is sparse.
See also: extract