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Somatostatin analogue used to treat secretory diarrheal states and gastrointestinal bleeding.
octreotide/oc·tre·o·tide/ (ok-tre´o-tīd) a synthetic analogue of somatostatin, used as the acetate ester in the palliative treatment of the symptoms of gastrointestinal endocrine tumors and in the treatment of acromegaly.
an antidiarrheal and hormone.
indications The two brand names of this drug are used for different purposes. Sandostatin is used to treat acromegaly, carcinoid tumors, and vasoactive intestinal peptide tumors (VIPomas). Sandostatin LAR Depot is used for long-term maintenance of acromegaly, carcinoid tumors, and VIPomas.
contraindications Known hypersensitivity to this drug prohibits its use.
adverse effects Life-threatening effects include seizure, arrhythmias, congestive heart failure, hepatitis, GI bleeding, and pancreatitis. Other adverse effects are depression, anxiety, tremors, paranoia, chest pain, shortness of breath, thrombophlebitis, ischemia, hypertension, palpitations, galactorrhea, diabetes insipidus, increased liver function tests, urinary tract infection, pollakiuria, hematoma and inflammation of the injection site, bruising, rash, urticaria, and pain. Common side effects include headache, dizziness, fatigue, weakness, sinus bradycardia, conduction abnormalities, hyperglycemia, ketosis, hypothyroidism, hypoglycemia, diarrhea, nausea, abdominal pain, vomiting, flatulence, distension, constipation, and joint and muscle pain.
octreotideAn hormone inhibitor analogue of the natural substance SOMATOSTATIN. Octreotide has a much longer effective time of action than somatostatin and is selective in its action on secretion of growth hormone, GASTRIN, SECRETIN and MOTILIN. It is also effective against various tumours of the ENDOCRINE system. A brand name is Sandostatin.
a somatostatin analog used in the treatment of endocrine disorders of the pituitary and pancreas.