obestatin


Also found in: Wikipedia.

obestatin

A peptide hormone derived from a prohormone, preproghrelin—which also contains ghrelin—by post-translational processing, originating from endocrine cells in the stomach. Obestatin is encoded by GHRL on chromosome 3p26-p25. The ratio of obestatin and ghrelin is altered in obesity and in anorexia nervosa. Initially reported as an anorexigenic hormone, recent data suggest that obestatin inhibits thirst and anxiety, improves memory, regulates sleep, affects cell proliferation, and increases secretion of the exocrine pancreas. Antisense transcripts for GHRL have been identified which regulate ghrelin-obestatin preproprotein expression.
References in periodicals archive ?
Plasma ghrelin and obestatin levels are increased in spontaneously hypertensive rats.
Distribution of obestatin and ghrelin in human tissues: Immuno-reactive cells in the gastrointestinal tract, pancreas and mammary glands.
Treatment with either obestatin or ghrelin attenuates mesenteric ischemia--reperfusion-induced oxidative injury of the ileum and the remote organ lung.
Cord blood chemerin and obestatin levels in large for gestational age infants," Journal of Maternal Fetal and Neonatal Medicine, vol.
Exercise regulates the secretion of biomolecules, such as ghrelin, leptin, obestatin, and visfatin, that function in energy metabolism and in many body systems (2-6).
The precursor to ghrelin, the pre-proghrelin, is formed in the post-transcriptional process of GHLR, it consists of 518 pb encoded in a sequence of117 amino acids, distributed over 23 amino acids of the signal peptide and 94 amino acids of pro-ghrelin, which include 28 amino acids of the mature ghrelin and over 66 additional amino acids (73), which include 23 of obestatin (a hormone with the antagonistic characteristics of ghrelin, which suppresses appetite and stomach activity) (74).
Obestatin peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.
6) Few number of anorexigenic peptide which compete against ghrelin on appetite regulation are leptin and obestatin.
2010) Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets.
The scientists isolated an appetite suppressing hormone, dubbed obestatin, which, when injected into rats, suppressed food intake by about 50% compared with rats not given the hormone.
The hormone, called obestatin, has yet to be tested on humans, but other obesity researchers have speculated that odds are very good the results will hold up in people as well.
found that administration of exogenous obestatin accelerates the healing of acetic acid-induced colitis, an effect partly due to anti-inflammatory properties of obestatin that reduces IL-1[beta] concentration and myeloperoxidase activity in colonic mucosa.