obestatin


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obestatin

A peptide hormone derived from a prohormone, preproghrelin—which also contains ghrelin—by post-translational processing, originating from endocrine cells in the stomach. Obestatin is encoded by GHRL on chromosome 3p26-p25. The ratio of obestatin and ghrelin is altered in obesity and in anorexia nervosa. Initially reported as an anorexigenic hormone, recent data suggest that obestatin inhibits thirst and anxiety, improves memory, regulates sleep, affects cell proliferation, and increases secretion of the exocrine pancreas. Antisense transcripts for GHRL have been identified which regulate ghrelin-obestatin preproprotein expression.
References in periodicals archive ?
Mide dokusu, ozellikle oksintik mukozasi ghrelin ve obestatin icin en zengin dokudur.
Calismaya dahil edilen her olgudan, ghrelin ve obestatin hormonlari icin sabah saat dokuzda 5 mL aclik kani ve 3 mL tukuruk eszamanli olarak alindi.
Calismaya alinan hastalarin serum, tukuruk ve idrar orneklerinde ghrelin ve obestatin duzeyleri olculdu.
Osteoporoz grubundaki hastalarin tedavi oncesinde ve sonrasinda olculen serum ile tukuruk acil ghrelin, deacil ghrelin ve obestatin duzeyleri ile kontrol grubunda olculen serum ve tukuruk acil ghrelin, deacil ghrelin ve obestatin duzeyleri arasindaki farkliliklar Tablo 3 ve Tablo 4'de gosterilmistir.
Bu calismada postmenopozal osteoporozlu kadinlarin serum acil ghrelin, deacil ghrelin, obestatin ve tukuruk acil ghrelin duzeylerinde, osteoporozu olmayan saglikli post-menopozal kadinlara gore anlamli farklilik saptanmadi.
Calismamizda tedavi oncesi hasta grubunda kontrol grubuna oranla, tukuruk obestatin duzeyinde istatistiksel olarak anlamli degerde dusukluk ve deacil ghrelin duzeylerinde ise yukseklik oldugu saptandi, serum seviyelerinde ise farklilik saptanmadi.
Genetic selection for body weight in chickens has altered responses of the brain's AMPK system to food intake regulation effect of ghrelin, but not obestatin.
2010) Proghrelin peptides: Desacyl ghrelin is a powerful inhibitor of acylated ghrelin, likely to impair physiological effects of acyl ghrelin but not of obestatin A study of pancreatic polypeptide secretion from mouse islets.
The scientists isolated an appetite suppressing hormone, dubbed obestatin, which, when injected into rats, suppressed food intake by about 50% compared with rats not given the hormone.
The hormone, called obestatin, has yet to be tested on humans, but other obesity researchers have speculated that odds are very good the results will hold up in people as well.
Another hormone, ghrelin, induces appetite--and scientists were surprised to find that both this hormone and obestatin are products of the same gene.