obesogen

(redirected from Obesogens)

obesogen

An exogenous substance that alters lipid homeostasis and fat storage, changes metabolic setpoints, disrupts energy balance or modifies the regulation of appetite and satiety, promoting fat accumulation and obesity.

Mechanisms of action
Alteration of metabolic sensing, neuroendocrine effects, cell signalling, dysregulation of steroid hormones.

Obesogens
Pharmaceutical obesogens
• Metabolic sensors—Act on PPAR-gamma receptor (e.g., thiazolidinediones, rosiglitazone);
• Sex steroid dysregulation—DES caused obesity in adults;
• Central—Act on neurotransmitter receptors (e.g., SSRIs, antidepressants).

Environmental obesogens
• Organotin;
• Xernobiotics.
References in periodicals archive ?
In particular, early-life exposure to obesogens may result in a higher susceptibility to developing obesity (Gran and Blumberg 2006; Heindel et al.
Moreover, data are sparse on how obesogens affect metabolism and the feeding axis and there are fundamental gaps in our understanding of the precise mechanisms by which environmental chemicals exacerbate this human disease.
It can be more challenging to lose weight than some people think, and environmental toxins called obesogens may be one reason why," says Sara Gottfried, MD, author of The Hormone Reset Diet.
In addition to age at menarche, higher levels of testosterone, estrogen and certain estrogen receptors were also found which explains why many studies have also found a link between in utero and postnatal exposure to ED chemicals such as PDBEs, PFOAs and dioxins (now termed obesogens for their ability to disrupt leptin and other adipose tissue signaling), and low birth weight, neurological developmental delays and later development of depression, adiposity and diabetes.
Adult exposure to obesogens has also been shown to trigger weight gain and other endocrine issues while exacerbating the effects of earlier exposure.
Identified in 2006 by Bruce Blumberg, professor of developmental and cell biology at the University of California, Irvine, obesogens are part of a larger group of synthetic chemicals known as endocrine disruptors.
Two of three experiments they are working on have to do with obesogens, which she described as "compounds that we can get from our diet or industrial products like plastics that may predispose people to weight gain.
He and his colleagues first identified the role of obesogens in a 2006 publication and showed in 2010 that TBT acts in part by modifying the fate of mesenchymal stem cells during development, predisposing them to become fat cells.
Obesogens "trick" our bodies into thinking they are natural hormones.
MascareSas will discuss the health implications of transportation and community planning, food and environment, and focus on the emerging science and the policy debate around obesogens (chemicals linked to obesity).
Obesity is known to be caused by a mismatch between caloric intake and energy expenditure, but early-life exposure to obesogens, including perfluoroalkyl substances (PFAS), may play a role (Holtcamp 2012; La Merrill and Birnbaum 2012).