LEP

(redirected from Obesity factor)
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LEP

A gene on chromosome 7q31.3 that encodes leptin, a protein secreted by white adipocytes, which plays a key role in regulating body weight. By binding to its cognate receptor, leptin is part of a signalling pathway which inhibits food intake and regulates energy expenditure to maintain fat homeostasis. Leptin plays a role in the endocrine system, and is involved in regulating immune and inflammatory responses, haematopoiesis, angiogenesis, reproduction, glucose homeostasis, bone formation, and wound healing.

Molecular pathology
Mutations of LEP and/or its regulatory regions are linked to obesity, morbid obesity with hypogonadism, and type-2 diabetes.

LEP

low egg passage, with reference to virus attenuation usually for vaccine production.
References in periodicals archive ?
5 per 100,000 children under 14 in the UK are diagnosed every year with Type 1 diabetes which, unlike the other main strand, Type 2, is not linked to lifestyle or obesity factors.
Obesity factors related to ART success take on less significance in older patients, she noted, "because obviously the strongest driver in your older patients is age.
The purpose of this project was to address obesity factors by increasing availability and improving sensory appeal of fruits and vegetables, while employing hands-on activities by learning to use hydroponic growing methods.