WT1

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WT1

A gene on chromosome 11p13 that encodes a transcription factor with a central role in urogenital development. WT1 displays complex tissue-specific and polymorphic imprinting pattern, with biallelic and monoallelic expression from the maternal and paternal alleles in different tissues. WT1 mRNA undergoes RNA editing, a tissue-restricted and developmentally regulated process.

Molecular pathology
WT1 is mutated in a small subset of patients with Wilm's tumours.