IPO.bb.11

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IPO.bb.11

A gene on chromosome 5q12.1 that encodes importin 11, a member of the karyopherin/importin-beta family of transport receptors, which plays a key role in nuclear protein import as a transport receptor for nuclear localisation signals on cargo substrates. It mediates docking of the importin/substrate complex to the nuclear pore complex by binding to nucleoporin; the complex is subsequently translocated through the pore by an energy-requiring, Ran-dependent mechanism.