NEDD8

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NEDD8

A gene on chromosome 14q12 that encodes a ubiquitin-like protein that plays an important role in cell cycle control and embryogenesis. Covalent attachment of NEDD8 to its substrates (neddylation) requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates E3 ubiquitin ligase activity, promoting polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.