IRF4

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IRF4

A gene on chromosome 6p25-p23 that encodes a member of the interferon regulatory transcription factor (IRF) family, which is characterised by an unique tryptophan pentad-repeat DNA-binding domain. IRF4 is lymphocyte specific and negatively regulates Toll-like-receptor (TLR)-signalling, which is central to activating the innate and adaptive immune systems.

Molecular pathology
A chromosomal translocation involving IRF4 and the IgH locus, t(6;14)(p25;q32), has been linked to myeloma.
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