ovarian hyperstimulation syndrome

(redirected from OHSS)
Also found in: Acronyms.

ovarian hyperstimulation syndrome

iatrogenic development of ovarian hyperstimulation that occurs when the luteotropic effects of human chorionic gonadotropin are exaggerated in a cycle in which ovarian stimulation has been done as a component of infertility treatment. The human chorionic gonadotropin is administered exogeneously to trigger ovulation after gonadotropin stimulation. It is present endogenously after implantation. Syndrome includes, to varying degrees, abdominal distention, potentially massive ovarian enlargement, and third spacing of vascular volume. It can range from moderate discomfort to life-threatening ovarian enlargement and fluid shifts.

ovarian hyperstimulation syndrome

,

OHSS

A potentially life-threatening complication that may occur in women receiving drugs to stimulate ovulation. The acute onset occurs within the first week ovulation is induced and is characterized by marked cystic ovarian enlargement, ascites, hydrothorax, arterial hypotension, tachycardia, hemoconcentration, oliguria, sodium retention, hypernatremia, and in severe cases renal failure. The condition is usually mild if the diameter of the ovary is less than 8 cm; moderate if 8 to 12 cm; and severe if greater than 12 cm.

Treatment includes symptomatic therapy to maintain circulatory function, bedrest, a low-sodium diet, and diuretic therapy. The life-threatening possibility can be avoided with close monitoring and withholding of drugs if ovarian response becomes excessive.

ovarian hyperstimulation syndrome

Ovarian enlargement, the production of multiple ovarian cysts, increased capillary permeability with generalized oedema and intravascular fluid depletion, SHOCK, and sometimes even death. The syndrome, which is uncommon, is caused by gonadotropin medical treatment to stimulate ovulation. Rarely, it may occur spontaneously during pregnancy as a result of a mutation in the gene for the follicle-stimulating hormone receptor.
References in periodicals archive ?
The key to prevent OHSS is recognition of risk factors for the syndrome and the experience with ovulation stimulation.
The OHSS incidence rate was also slightly higher than that of the LE group, but the clinical pregnancy rates of the two groups were similar.
In this prospective observational follow-up study, we included 114 patients who showed a predisposition to developing OHSS during controlled ovarian stimulation before IVF/intracytoplasmic sperm injection (ICSI) and had undergone coasting at the Royan Institute Research Center, Iran, between June 2010 and December 2012.
We present a case of acute cerebral thrombosis with OHSS following ovarian induction.
Other effective strategies to prevent OHSS are already in clinical practice, and the new drug would have to go through large clinical trials to confirm its efficacy, safety and equivalence to these other medications currently in use," he added.
Furthermore, they also tend to have higher serum oestradiol levels, resulting in an increased risk of OHSS.
In extreme cases, OHSS can cause severe morbidity and even death.
OHSS, he further explained, combines the benefits of hosted services, which also include scalability and geographic redundancy, with the security and control that were previously available only in premises-based solutions.
Grade 5: Hemokonsantrasyon, koagulasyon bozuklugu, renal yetmezlik olarak OHSS klinigi ortaya konmaktadir.
With OHSS, we are offering our large-business and government customers the best of both worlds.