oral glucose tolerance test

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oral glucose tolerance test



A screening test for diabetes mellitus (DM), in which plasma glucose levels are measured after the patient consumes an oral glucose load. In screening patients for type 2 DM, measuring fasting plasma glucose levels or checking a hemoglobin A1c level is generally preferable to an OGTT because the former tests are simpler, cheaper, and better tolerated by patients. An OGTT reveals type 2 DM when plasma glucose levels exceed 200 mg/dl 2 hr after drinking a 75-g glucose load. Plasma glucose levels between 140 mg/dl and 199 mg/dl suggest impaired glucose tolerance.

Gestational Diabetes Mellitus

In pregnancy, a modified OGTT is used to screen women with risk factors for gestational diabetes (GDM), including obesity, family history of type 2 DM, age greater than 25 years, and a history of unexplained stillbirths. At 24 to 28 weeks' gestation, a 50-g glucose load is given; 1-hr plasma glucose levels greater than 140 mg/dl constitute a positive screening result. Any patient having a positive test result should then undergo a 2-hr, 100-g OGTT to determine whether GDM is present. See: table

Screen high-risk women at first visit, and screen all women at 24–28 weeks' gestation with 75g oral glucose tolerance test. American Diabetes Association revised Standards of Medical Care, published in Diabetes Care special supplement, January 2011. International Association of Diabetes and Pregnancy Study Groups published in Leary, J. et al. (2010). Best Practice Research Clinical Endocrinology and Metabolism 24 (4), 673.
Time:Glucose level exceeds:
Fasting92 mg/dl
60 min180 mg/dl
120 min155 mg/dl
180 min140 mg/dl

oral glucose tolerance test

glucose tolerance test
References in periodicals archive ?
It is important to highlight that the majority of these studies were cross-sectional, and some lacked accurate biomarkers of exposure, had limited information on metabolic or glycemic biomarkers, and/or relied on self-reported diabetes prevalence not confirmed with OGTT or fasting glucose levels.
s study [sup][12] in this issue shows that various characteristics of OGTT were associated with different adverse outcomes.
All children with diabetes were detected using the combined OGTT and HbA1C tests.
2%) were found at risk for GDM during GCT and were included in the 3-h, 100-g diagnostic OGTT.
Our study showed that the levels of LDL, total cholesterol, LAP, HDL/ TG ratio, CRP, TGs, HOMA-IR, as well as glucose and insulin levels at 2 hours after OGTT were significantly higher in the PCOS group with elevated BMI as compared to the PCOS group with normal body weight.
During OGTT, none of them had the values of fasting glycemia and 2 hours post-load typical for diabetes.
An OGTT was performed with 75 g dextrose (Trutol 75; Custom Laboratories).
The mean difference in random plasma glucose, one-hour OGTT, two-hour OGTT, and two-hour postprandial glucose significantly higher in GDM cases compared to control indicating that the glucose intolerance is significantly associated with the incidence of GDM.
Inclusion criteria were at least one abnormal plasma glucose value at screening OGTT as per IADPSG criteria who failed to achieve glycaemic targets with trial of diet modifications and exercises for 1 week.
Caption: Figure 1: Change of glucose and insulin among 3 groups in OGTT.
Research has shown that the OGTT is more sensitive than the FPG test for diagnosing prediabetes, but it is less convenient to administer.