POU2F1

(redirected from OCT1)
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POU2F1

A gene on chromosome 1q24.2 that encodes a ubiquitous transcription factor which binds to and activates the promoters of genes for small nuclear RNAs (snRNA), as well as for histone H2B and immunoglobulins. It modulates transcription transactivation by NR3C1, AR and PGR.
References in periodicals archive ?
Hence, genes for drug transporters, such as MDR1 and OCT1 will prove to be as important as the Cytochrome P450 system in determining plasma and tissue levels of drugs, and thereby the efficacy and toxicity of drugs in disease areas including but not limited to oncology, cardiology, CNS, metabolic, and inflammatory diseases and pain.
In addition, the genes CYP2B6, OCT1, and MRP1 are implicated in the absorption, distribution, and metabolism of many drugs that span a variety of therapeutic classes and indications, and are likely to be important in both response and safety profiles for these drugs.
To explore quantitative detection of multiple DNA-binding proteins in the nuclear extracts, we selected 10 important transcription factors as target proteins, including SP1, AP2, NFAT, SRE, EGR, YY1, AP1, CREB, OCT1, and NF-[kappa]B; detailed information is summarized in Table 1 in the online Data Supplement.