POU2AF1

(redirected from OCA-B)

POU2AF1

A gene on chromosome 11q23.1 that encodes a transcription coactivator that recognises the POU domains of OCT1 and OCT2, boosting OCT1 mediated promoter activity and, to a lesser extent, that of OCT2. POU2AF1 is essential for B-cell response to antigens and required for germinal centre formation.
References in periodicals archive ?
They found that in helper T (CD4+) cells, the proteins Oct1 and OCA-B work together to put immune response genes on standby so that they are easily activated when the body is re-exposed to a pathogen.
identified OCA-B as being the additional factor required for a robust immune response in resting helper T cells.
To further investigate the importance of Oct1 and OCA-B in immunological memory, the researchers examined mice lacking either one of the two genes.