number needed to treat

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number needed to treat

In a clinical treatment regimen, the numeric cohort of patients who must be treated to prevent the occurrence of specified complications or adverse outcomes of the condition under examination.

number needed to treat

Decision-making The minimum number of Pts to whom a particular intervention must be administered in a trial or controlled study to prevent a single target event. See Absolute risk reduction, Odds ratio, Relative risk reduction, Threshold NNT.

number needed to treat

The number of patients who must receive a specific therapy (or undergo a specific medical test) so that one of them will benefit. This concept is important in assessing the relative values and costs of interventions for specific illnesses. For example, to prevent one death from breast cancer, the number of patients who need annual mammography can be calculated. Similarly, the number of patients with cancer who will survive because of the use of a particular chemotherapy can be assessed. Generally, the smaller the number needed to treat, the greater the value of the intervention. This comparative information can be used to decide how to allocate resources, plan studies, or make recommendations to patients about their care.
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Earlier this year, the Safety and Efficacy of Solitaire Stent Thrombectomy - Individual Patient Data Meta-analysis of Randomized Trials (SEER)3, a meta-analysis of SWIFT PRIME3, Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours (REVASCAT)4, EXtending the Time for Thrombolysis in Emergency Neurological Deficits - Intra-Arterial (EXTEND-IA)5 and Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE)6, showed a strong significance in the numbers needed to treat (2.
You can see the incredibly low numbers needed to treat here.
Therefore, the numbers needed to treat to save one life ranged from 11-20 patients.
Further research is needed to confirm these findings and to identify the numbers needed to treat to prevent one case from progressing from early to late AMD.
Waldman does quote the evidence when it is available but does not seem to like numbers needed to treat when discussing drug treatment.
Adverse effects were more common in the treated patients, with numbers needed to treat to harm of 12 to 78 in the significant studies.
To provide perspective, the following discussion focuses on the absolute risk reduction and the numbers needed to treat associated with two preventive health measures that have been widely researched and endorsed: (1) preventing coronary artery disease by treating hypercholesterolemia and (2) preventing fractures by treating osteoporosis.
Second, a lot of clinicians have a tendency to enjoy numbers less, and so working with likelihood ratios, or numbers needed to treat, or absolute risk reduction sometimes seems a bit intimidating.