salvage pathway

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sal·vage path·way

the use of preformed purine and pyrimidine bases to synthesize nucleotides.

salvage pathway

Oncology A popular term for a metabolic pathway that uses substrates other than the usual biosynthetic intermediates for a product–eg,
1. The salvage of free purines from the hydrolysis of nucleotides for the generation of new nucleotides, or.
2. The 2º pathway of nucleotide synthesis, in which thymidylate is produced by thymidine kinase from thymidine, rather than the usual path in which deoxyuridylate is methylated by thymidylate synthetase into thymidylate, a pathway utilized by Pts with megaloblastic anemia. See Leucovorin 'rescue. '.
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