Nucleoside analogues


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Nucleoside analogues

The first group of effective anti-retroviral medications. They work by interfering with the AIDS virus' synthesis of DNA.
Mentioned in: AIDS
References in periodicals archive ?
Chemists and pharmacists here explore some of the techniques used to synthesize nucleoside analogues.
BOSTON -- Recent use of the nucleoside analogues abacavir and didanosine is associated with a significantly increased risk of myocardial infarction in HIV-infected individuals, whereas treatment with the thymidine analogues appears to convey no such risk, according to findings presented at the 15th Conference on Retroviruses and Opportunistic Infections.
Currently, the production of purine nucleoside analogues by chemical routes is time-consuming, complicated and expensive.
Mitox(tm) has potential applications as part of the treatment for highly active antiretroviral (HAART) HIV-1 treatment and other antiviral treatments using nucleoside analogues.
An increase of lactic acid in the blood (lactic acidosis), which can cause death, has been reported in patients taking REYATAZ with other anti-HIV medicines called nucleoside analogues.
Approved March 14, 1996 for use alone or in combination with nucleoside analogues for the treatment of HIV infection in adults.
In this research, Frost & Sullivan's expert analysts thoroughly examine the following applications: hepatitis B drug therapies - nucleoside analogues, interferons, and vaccines.
Initial treatment regimens for chronic HBV consist of monotherapy with interferon-[alpha], pegylated interferon-[alpha], or nucleoside analogues.
Severe lactic acidosis is an infrequent, but well-described complication of the class of HIV drugs known as nucleoside analogues.
Inhibitex is developing a series of phosphoramidate nucleoside analogues, or protides, which target the RNA-dependent RNA polymerase (NS5b) of HCV.
31 per 100 patient-years in 55 patients treated with antiretroviral nucleoside analogues and a mortality of 7.
Nucleoside analogues are a class of drugs that affect DNA synthesis.

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