It was logical to assume that [alpha], [beta]-unsaturated ketone group in the each diterpenoids could undergo the nucleophilic addition with nucleophile
compounds such as L-cysteine in DMEM.
Substitution reactions can be carried out with nucleophiles
, such as sodium phenoxide, to form hydrolytically stable polymers.
Gold-Catalyzed Addition of Nitrogen and Sulfur Nucleophiles
to C-C Multiple Bonds.
These conditions were selected on the basis of our previous experience, various substrates and nucleophiles
, as they gave high and almost quantitative modification degrees (25), (31).
Therefore, they preferably react with nucleophiles
, especially thiol groups of proteins as well as the free intracellular glutathione, by a Michael-type addition (Zhang et al 2005).
Countless reactions have been performed using a wide range of soluble nucleophiles
, including aldol condensations, Michael additions, homoenolate reactions, pericyclic reactions, and transesterification reactions.
This side chain also interacts with nucleophiles
to form adducts: the presumed cathepsin inhibitory activity is thought to reside in the active cysteine of cathepsin B, H, and L and of papain (Sudaranam et al.
The mechanistic pathway is dependent on the presence of water or other nucleophiles
These fluorocarbon elastomers are known to be highly susceptible to attack by nucleophiles
such as amines.
This unprecedented type of metal-diene bonding results in the bound dienes exhibiting unusual reactivity patterns, particularly towards nucleophiles
such as ketones.
This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles
In second step, 2-tienyllithium acted as nucleophiles
and reacted with DCPP to give BTPP.