NCOA3

(redirected from Nuclear receptor coactivator 3)
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NCOA3

A gene on chromosome 20q12 that encodes a nuclear receptor coactivator, which interacts with nuclear hormone receptors to enhance transcription. NCOA3 has histone acetyltransferase activity and recruits other proteins, forming a multi-unit coactivation complex. It first appears in the cytoplasm but is translocated into the nucleus upon phosphorylation.
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Seven SNP loci from 5 genes, ESR1, estrogen receptor 2 (ESR2), nuclear receptor coactivator 3 (NCOA3), peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B), and related RAS viral (rras) oncogene homolog 2 (RRAS2, alias TC21) with different minor allele frequencies were genotyped (Table 1 and Table 2) by using MALDI-TOF mass spectrometry (MS) according to manufacturer's instructions (Sequenom MassARRAY platform).
Two of the best-studied of these novel prognostic markers are osteopontin and nuclear receptor coactivator 3 (NCOA3).
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