noncompetitive inhibition

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inhibition

 [in″hĭ-bish´un]
1. arrest or restraint of a process.
2. in psychoanalysis, the conscious or unconscious restraining of an impulse or desire. adj., adj inhib´itory.
competitive inhibition inhibition of enzyme activity by an inhibitor (a substrate analogue) that competes with the substrate for binding sites on the enzymes.
contact inhibition inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
noncompetitive inhibition inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.

non·com·pet·i·tive in·hi·bi·tion

a type of enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme but inhibits the reaction by combining with the enzyme-substrate complex as well as with the free enzyme.

noncompetitive inhibition

[-kəmpet′itiv]
(in pharmacology) a form of inhibition in which a substance (drug) occupying a receptor cannot be displaced from the receptor by increasing the number of other molecules through the principle of mass action. The drug is irreversibly bound to the receptor.

non·com·pet·i·tive in·hi·bi·tion

(non'kŏm-pet'i-tiv in'hi-bish'ŭn)
A type of enzyme inhibition in which the inhibiting compound does not compete with the natural substrate for the active site on the enzyme, but inhibits the reaction by combining with the enzyme-substrate complex, after the latter has been formed, and with the free enzyme.

noncompetitive inhibition

a form of enzyme control in which the enzyme has two kinds of ACTIVE SITE, one for an inhibitor, the other for the enzyme substrate. The inhibitor prevents catalytic activity of the enzyme, perhaps by locking or even changing the shape of the substrate active site. Compare COMPETITIVE INHIBITION. See also ALLOSTERIC ENZYME.

inhibition

arrest or restraint of a process.

competitive inhibition
inhibition of enzyme activity by an inhibitor (a substrate analog) that competes with the substrate for binding sites on the enzymes.
contact inhibition
inhibition of cell division and cell motility in normal animal cells when in close contact with each other.
end-product inhibition
see feedback inhibition (below).
feedback inhibition
a common way of regulating enzyme activity in which the reaction product (or in the case of a biosynthetic pathway, the product of the reaction sequence) inhibits the enzyme activity. Called also end-product inhibition.
neurological inhibition
the intermittency of transmission of nervous impulses depends on variations in the balance between excitation and inhibition, the latter being either pre- or postsynaptic.
noncompetitive inhibition
inhibition of enzyme activity by substances that combine with the enzyme at a site other than that utilized by the substrate.
References in periodicals archive ?
51[micro]M, and the possible mechanism of inhibition is shown the characteristic of noncompetitive inhibitors.
Dihydrotanshinone was not only a potent competitive inhibitor of human CYP1A2 and CYP2C9, but also a potent noncompetitive inhibitor of human CYP3A4.
The inhibition kinetics analyses unveil that compounds 1 and 2 are noncompetitive inhibitors.
Cysteine based novel noncompetitive inhibitors of urease (s) distinctive inhibition susceptibility of microbial and plant ureases.
As noncompetitive inhibitors of the enzyme reverse transcriptase, their antiviral activity is additive or synergistic with other antiretroviral agents.
This alkaloid inhibited AChE in the same fashion as some AD drugs including donepezil, tacrine and rivastigmine which are noncompetitive inhibitors (Zhao and Tang 2002).