hydrops fetalis (redirected from Non-immune)

Hydrops fetalis

A condition in which a fetus or newborn baby accumulates fluids, causing swollen arms and legs and impaired breathing.

Mentioned in: Erythroblastosis Fetalis

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hydrops fetalis,

massive edema in the fetus or newborn, usually in association with severe erythroblastosis fetalis. Severe anemia and effusions of the pericardial, pleural, and peritoneal spaces also occur. The condition usually leads to death, even with immediate exchange transfusions after delivery. Also called fetal hydrops.

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hydrops [hi´drops] (L.)

old term for edema. adj., adj hydrop´ic.

fetal hydrops (hydrops feta´lis) gross edema of the entire body of the newborn infant, in erythroblastosis fetalis.

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hydrops fetalis

Kernicterus, Rh incompatibility, Rh-induced hemolytic disease of newborn Obstetrics An accumulation of fluid in neonates, resulting in a 'puffy', plethoric or hydropic appearance that may be due to various etiologies Clinical Ascites, edema, ↓ protein or chronic intrauterine anemia, hepatosplenomegaly, cardiomegaly, extramedullary hematopoiesis, jaundice, pallor COD Heart failure. See Hemolytic disease of the newborn.

Hydrops Fetalis, causes

Immune Mother produces IgG antibodies against infant antigen(s), often an RBC antigen, most commonly, anti-RhD, which then passes into the fetal circulation, causing hemolysis

Non-immune Hydrops may result from various etiologies including

•  Fetal origin, eg congenital heart disease (premature foramen ovale closure, large AV septal defect), hematologic (erythroblastosis fetalis, α-thalassemia due to hemoglobin Barts, chronic fetomaternal or twin-twin transfusion), infection (CMV, herpesvirus, rubella, sepsis, toxoplasma), pulmonary (cystic adenomatoid malformation, diaphragmatic hernia, with pulmonary hypoplasia, lymphangiectasia), renal (vein thrombosis, congenital nephrosis) and teratomas, skeletal malformations (achondroplasia, osteogenesis imperfecta, fetal neuroblastomatosis, storage disease, meconium peritonitis, idiopathic)

•  Placental Chorangioma, umbilical or chorionic vein thrombosis

•  Maternal DM, toxemia