lymphoma /lym·pho·ma/ (lim-fo´mah) any neoplastic disorder of lymphoid tissue. Often used to denote malignant l., classifications of which are based on predominant cell type and degree of differentiation; various categories may be subdivided into nodular and diffuse types depending on the predominant pattern of cell arrangement.
Non-Hodgkin's lymphoma
non-Hodgkin's lymphoma (NHL)
non-Hodgkins' lymphoma
adult T-cell lymphoma , adult T-cell leukemia/lymphoma see under leukemia.
B-cell lymphoma any in a large group of non-Hodgkin's lymphomas characterized by malignant transformation of the B lymphocytes.
B-cell monocytoid lymphoma a low-grade lymphoma in which cells resemble those of hairy cell leukemia.
Burkitt's lymphoma a form of small noncleaved-cell lymphoma, usually occurring in Africa, manifested usually as a large osteolytic lesion in the jaw or as an abdominal mass; Epstein-Barr virus has been implicated as a causative agent.
centrocytic lymphoma mantle cell l.
convoluted T-cell lymphoma lymphoblastic lymphoma with markedly convoluted nuclei.
cutaneous T-cell lymphoma a group of lymphomas exhibiting (1) clonal expansion of malignant T lymphocytes arrested at varying stages of differentiation of cells committed to the series of helper T cells, and (2) malignant infiltration of the skin, which may be the chief or only manifestation of disease.
diffuse lymphoma in an older classification method, malignant lymphoma in which the neoplastic cells diffusely infiltrate the entire lymph node, without any definite organized pattern.
follicular lymphoma any of several types of non-Hodgkin's lymphoma in which the lymphomatous cells are clustered into nodules or follicles.
follicular center cell lymphoma B-cell lymphoma classified by the similarity of the cell size and nuclear characteristics to those of normal follicular center cells; the four previous subtypes are scattered among several types of follicular and diffuse lymphomas.
giant follicular lymphoma follicular l.
granulomatous lymphoma Hodgkin's disease.
histiocytic lymphoma a rare type of non-Hodgkin's lymphoma characterized by the presence of large tumor cells resembling histiocytes morphologically but considered to be of lymphoid origin.
Hodgkin's lymphoma see under disease.
intermediate lymphocytic lymphoma , lymphocytic lymphoma, intermediately differentiated mantle cell l.
large cell lymphoma any of several types of lymphoma characterized by the formation of one or more types of malignant large lymphocytes, such as large cleaved or noncleaved follicular center cells, in a diffuse pattern.
large cell, immunoblastic lymphoma a highly malignant type of non-Hodgkin's lymphoma characterized by large lymphoblasts (B or T lymphoblasts or a mixture) resembling histiocytes and having a diffuse pattern of infiltration.
Lennert's lymphoma a type of non-Hodgkin's lymphoma with a high content of epithelioid histiocytes and frequently with bone marrow involvement.
lymphoblastic lymphoma a highly malignant type of non-Hodgkin's lymphoma composed of a diffuse, relatively uniform proliferation of cells with round or convoluted nuclei and scanty cytoplasm.
malignant lymphoma a group of malignancies characterized by the proliferation of cells native to the lymphoid tissues, i.e., lymphocytes, histiocytes, and their precursors and derivatives; the group is divided into two major clinicopathologic categories: Hodgkin's disease and non-Hodgkin's lymphoma.
mantle cell lymphoma , mantle zone lymphoma a rare form of non-Hodgkin's lymphoma having a usually diffuse pattern with both small lymphocytes and small cleaved cells.
marginal zone lymphoma a group of related B-cell neoplasms that involve the lymphoid tissues in the marginal zone, the patchy area outside the follicular mantle zone.
mixed lymphocytic-histiocytic lymphoma non-Hodgkin's lymphoma characterized by a mixed population of cells, the smaller cells resembling lymphocytes and the larger ones histiocytes.
nodular lymphoma follicular l.
non-Hodgkin's lymphoma a heterogeneous group of malignant lymphomas, the only common feature being an absence of the giant Reed-Sternberg cells characteristic of Hodgkin's disease.
plasmacytoid lymphocytic lymphoma a rare variety of small lymphocytic lymphoma in which the predominant cell type is the plasma cell.
primary effusion lymphoma a B-cell lymphoma associated with human herpesvirus 8 infection, characterized by the occurrence of lymphomatous effusions in body cavities without the presence of a solid tumor.
small B-cell lymphoma the usual type of small lymphocytic lymphoma, having predominantly B lymphocytes.
small cleaved cell lymphoma a group of non-Hodgkin's lymphomas characterized by the formation of malignant small cleaved follicular center cells, with either a follicular or diffuse pattern.
small lymphocytic lymphoma a diffuse form of non-Hodgkin's lymphoma representing the neoplastic proliferation of well-differentiated B lymphocytes, with focal lymph node enlargement or generalized lymphadenopathy and splenomegaly.
small lymphocytic T-cell lymphoma small lymphocytic lymphoma that has predominantly T lymphocytes.
small noncleaved cell lymphoma a highly malignant type of non-Hodgkin's lymphoma characterized by the formation of small noncleaved follicular center cells, usually in a diffuse pattern.
T-cell lymphomas a heterogeneous group of lymphoid neoplasms representing malignant transformation of the T lymphocytes.
U-cell lymphoma , undefined lymphoma a category of non-Hodgkin's lymphomas that cannot be classified into a definite type by either morphologic or known immunocytochemical markers.
undifferentiated lymphoma small noncleaved cell l.
non-Hodg·kin's lymphoma (n n-hj k nz)n. Any of various malignant lymphomas characterized by the absence of Reed-Sternberg cells. |
Non-Hodgkin's lymphoma
Cancer that originates in the lymphatic system and typically spreads throughout the body.
Mentioned in: Beta 2 -Microglobulin Test
non-Hodgkin's lymphoma (NHL)
[- hoj′kənz]
any of a heterogeneous group of malignant tumors involving lymphoid tissue that do not have the Reed-Sternberg cell. NHLs differ in their histologic, immunologic, and clinical characteristics and their prognosis with therapy. An accurate diagnosis requires excision of at least one affected lymph node for biopsy evaluation by an experienced pathologist. In more than 10% of NHL patients, examination of different nodes may reveal different histologic findings. NHLs are classified into a dozen histologic grades and subtypes on the basis of nodal architecture, cell type, and clinical behavior. NHL is a disease of the middle years, usually in persons over 50 years of age. The rate of incidence is about 8.1 per 100,000 men and 5.7 per 100,000 women. The cause is unknown, but NHL may be the result of genetic damage. Immunosuppressed persons have a greater incidence of NHL, suggesting the presence of an immune mechanism. The probability of acquired immunodeficiency patients developing NHL has been estimated at more than 30%. Also called lymphosarcoma.
non-Hodgkins' lymphoma
A lymphoid cancer that is not Hodgkins disease: NHL ALL, B cell lymphoma, Burkitt's lymphoma, diffuse cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, lymphoblastic lymphoma, mantle cell
lymphoma, mycosis fungoides, post-transplantation lymphoproliferative disorder, small non-cleaved cell lymphoma, T-cell lymphoma Epidemiology Incidence ↑ 8.5/105 in 1973→15/105 in 1990 (21/105, in 2000, Canada ♂), ±53,900 new
cases/yr, US in 2002; 60% of all lymphomas are NHLs, of which 55% are diffuse, 45% are nodular Risk factors AIDS, primary immunodeficiency, immunosuppression, transplants, exposure to pesticides, hair dyes, smoking, alcohol, in older
♀–linked to ↑ consumption of meat/animal fats– Management Chemotherapy, especially CHOP Complications Spinal cord compression occurs in up to 10%, which is often aggressive, and may respond to high-dose RT. See Lymphoma, REAL
classification, Working Formulation.
Non-Hodgkin's lymphoma
Stage I CA present in only one lymph node area or in only one extranodal regional/organ
Stage II CA present in ≥ 2 lymph node areas on same side of diaphragm; CA present in only one extranodal area or organ outside the lymph nodes and in the lymph nodes around it. Other lymph node areas on the same side of the diaphragm may
also have cancer
Stage III CA present in lymphoid tissue on both sides of the diaphragm; tumor may also have spread to an area or organ near the lymph node areas and/or to the spleen
Stage IV CA has spread to > one organ or organs outside lymphoid tissue; CA has spread to only one organ outside the lymph system, but lymph nodes distant from that organ are involved
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