Devarajan and Dursun also suggested a dopaminergic nigrostriatal pathway
blockade-mediated "central mechanism", however, our case did not seem to comply with this mechanism, as quetiapine does not appear to block the dopaminergic nigrostriatal pathway
Parkinson's disease (PD) is a progressive neurodegenerative disorder secondary to the loss of dopaminergic neurons in the nigrostriatal pathway
: Dysfunction in the nigrostriatal pathway
, part of the basal ganglia, is associated with Parkinson's disease.
Imaging of dopamine receptors in the nigrostriatal pathway
under the influence of a typical antipsychotic drug reveals an almost total blockade (approaching 90% of receptor sites).
TH immunostaining demonstrated the destruction of nigral DA neurons and striatal DA fibers in LPS-injected Tg mice, whereas the nigrostriatal pathway in NS-injected Tg mice and all WT mice remained intact (Figure 1C,D).
Unlike LPS-injected Tg mice, NS-injected Tg mice and LPS-injected WT mice failed to develop chronic neuroinflammation (Figure 4), [alpha]-syn pathology (Figures 2 and 3), or detectable neuronal loss (Figures 1, 4, and 5) in the nigrostriatal pathway.
Microglial cells (immune cells resident in the brain) are activated in Parkinson's disease, producing pro-inflammatory factors that result in the death of nerve cells in an area of the brain called the nigrostriatal pathway
For example, in the nigrostriatal pathway dopamine causes inhibition of excessive muscle tone.
1] receptors are found in most of the dopaminergic pathways including the nigrostriatal pathway (within the basal ganglia).
It has been hypothesized that developmental insults could contribute to Parkinson disease (PD), a neurodegenerative disorder resulting from the loss of the dopamine neurons of the nigrostriatal pathway
Human Parkinson's disease is characterized by loss of the neurotransmitter dopamine in the nigrostriatal pathway
, resulting in marked impairment of movement and often accompanied by deficits in affect and cognition.
Although the mechanism underlying this head trauma-related development of permanent damage to the nigrostriatal pathway
remains unclear, it is possible that the initial neuronal damage leads to the activation of glial cells, whose activity may exacerbate the neurodegenerative process.