It is suggested that the ability to create NMS by neuroleptics is associated with their ability to block dopamine in the nigrostriatal pathway
, mesocortical pathway, and hypothalamic nucleus.
In PD, the nigrostriatal pathway
and the other two abovementioned patients can be affected.
The nigrostriatal pathway
as one of the four major DA pathways in the brain is particularly involved in the production of DA.
The dopaminergic nigrostriatal pathway
has been linked to the symptoms of PD (Bergman & Deuschl, 2002) because this pathway connects the substantia nigra (the source of dopaminergic neurons) with other parts of the basal ganglia and brain, facilitating coordinated movement.
The dopamine (DA) system in the CNS includes the nigrostriatal pathway
, the mesolimbic pathway and the tuberoinfundibular pathway.
Parkinson's disease (PD) is a progressive neurodegenerative disorder secondary to the loss of dopaminergic neurons in the nigrostriatal pathway
: Dysfunction in the nigrostriatal pathway
, part of the basal ganglia, is associated with Parkinson's disease.
Imaging of dopamine receptors in the nigrostriatal pathway
under the influence of a typical antipsychotic drug reveals an almost total blockade (approaching 90% of receptor sites).
TH immunostaining demonstrated the destruction of nigral DA neurons and striatal DA fibers in LPS-injected Tg mice, whereas the nigrostriatal pathway
in NS-injected Tg mice and all WT mice remained intact (Figure 1C,D).
maintains or moderately boosts dopamine activity as needed in regions such as the nigrostriatal pathway
High efficiency in the treatment of psychosis together with fewer side effects of atypical antipsychotic drugs are generally related with dopaminergic blockage in the mesolimbic pathway rather than the nigrostriatal pathway
and increased dopamine release due to serotoninergic blockage in the nigrostriatal pathway
It has been hypothesized that developmental insults could contribute to Parkinson disease (PD), a neurodegenerative disorder resulting from the loss of the dopamine neurons of the nigrostriatal pathway