50]) de 10 [micro]g/mL, en referencia a la CI50 para nifurtimox
y para benidazol, la cual debe ser menor a los 3 [micro]g/mL (Werner & Zulantay, 2011), por lo cual fueron seleccionados para continuar con este proyecto.
Igualmente, a partir de ese ano, como resultado del aumento de las evidencias cientificas (12-14) y gracias a las campanas para ampliacion del acceso al diagnostico y tratamiento para la enfermedad de Chagas (15, 16), se observo un ligero crecimiento de la demanda de benznidazol y nifurtimox
As the manufacturer of Nifurtimox
, one of only two treatments for Chagas' disease, we regard the fight against this disease as a long-term commitment, said Dieter Weinand, Member of the Board of Management of Bayer AG and President of Bayers Pharmaceuticals Division.
Como se menciono anteriormente, para el tratamiento de la tripanosomiasis americana solo se dispone actualmente de dos medicamentos: benznidazol y nifurtimox
In 2007, she said, nifurtimox
was the main drug available through CDC, while benznidazole, which is somewhat better tolerated and has shorter treatment duration, has since become the first-line agent.
By comparing the IC50 values it was observed that copper based Schiff base metal complex was more active than the tested compounds and even the standard compound Nifurtimox
Treatment with benznidazole or nifurtimox
should generally be offered to patients with acute T.
A combination of nifurtimox
and eflornithine has shown promising results in the treatment of second stage of African trypanosomiasis (18), but its use is marred by dangerous side-effects.
For instance, there are drugs to treat Chagas disease, like benznidazole and nifurtimox
, but they are hard to procure, often not effective in adults after the symptoms of heart disease begin and so toxic they cannot be taken by pregnant women.
Benznidazole and nifurtimox
, the antitrypanosomal drugs used to treat Chagas disease, are not Food and Drug Administration--approved in the United States, but they are available through CDC for use under investigational protocols.
In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox
1]) of L-tryptophan, nicotinic acid, picolinic acid and nicotinamide were prepared in water, and benznidazole and nifurtimox
were prepared in 10% DMSO (v [v.