neuroprotection


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neuroprotection

[noo͡r′ō·prō·tek′shən]
protection against neurotoxicity.

neuroprotection

(nūr″ō-prō-tĕk′shŭn)
The science of minimizing secondary neurologic damage following stroke or trauma. Certain drugs, enzymes, hormones, and physical actions, such as inducing hypothermia, may act as neuroprotectors.

neuroprotection

A therapeutic strategy aimed at preventing the ultimate result of a neurodegenerative disease process. Example: in current glaucoma therapy, the principal objective is to lower the intraocular pressure, but that appears to be only one of the risk factors that lead ultimately to shrinkage and/or death of retinal ganglion cells and visual field loss. Visual field losses occur even after the intraocular pressure is returned to within the normal range in some patients. Neuroprotection is aimed at preventing that secondary ganglion cell degeneration in glaucomatous eyes, which may have been caused as a result of inflammatory or toxic mediators released by the primary degenerative event. Neuroprotective strategies presently being evaluated include glutamate antagonists, calcium channel blockers, nitric oxide synthase inhibitors and neurotrophins.
References in periodicals archive ?
Since S1R agonists are known to be potent neuroprotectants in preclinical models, they might play a critical role in providing neuroprotection for patients with AD and related disorders.
While the metformin at the dose of (20mM) along with PTZ for 30 minutes showed neuroprotection against PTZ-induced neuronal cell loss by MTT assay and Western blot analysis.
Recent studies demonstrated the presence of CSF-receptor (G-CSFR) system in the brain and spinal cord, and their roles in neuroprotection and neural tissue repair, as well as improvement in functional recovery.
They also showed that feeding mice probiotics after a SCI confers neuroprotection and improves functional recovery.
Tenders are invited for purchase enroute transcarotid neuroprotection system, stents, inducers, and related items manufactured by silkroad medical or equal.
M2 PHARMA-April 15, 2016-US FDA Clears Silk Road Medical's Second Generation Enroute Transcarotid Neuroprotection System
ANAVEX 3-71 is a preclinical drug candidate with a novel mechanism of action through sigma-1 receptor activation and M1 muscarinic allosteric modulation, which has shown signs of improving neuroprotection and cognition in Alzheimer's disease.
TRADITIONAL USES: Antioxidant and peripheral vasodilator (brain support, cerebrovascular disorders, neuroprotection and tinnitus).
Previous relevant reviews on the potential for quercetin to exert neuroprotection have been published [29, 30].
Since publication of the findings of the CATIE study, the primary investigator has proposed that neuroprotection can be a therapeutic strategy to prevent neurodegeneration and neurodeterioration associated with schizophrenia.
Ablynx has entered into an exclusive research collaboration with Genzyme, a Sanofi company, to investigate Nanobodies against a multiple sclerosis (MS) target that relates to Genzyme's early-stage MS research programs involving neuroprotection and CNS repair.