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neurofibrillary tangles

   Also found in: Acronyms, Encyclopedia, Wikipedia 0.01 sec.
Neurofibrillary tangles
Abnormal structures, composed of twisted masses of protein fibers within nerve cells, found in the brains of people with Alzheimer's disease.
Mentioned in: Dementia

neurofibrillary tangles
[-fī′briler′ē]
an intracellular clump of neurofibrils made of insoluble protein in the brain of a patient with Alzheimer's disease.


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From the point of view of treating Alzheimer's disease, if we can express the mouse gene in human brain cells, we may be able to control the buildup of amyloid beta and tau neurofibrillary tangles.
The plaques, along with neurofibrillary tangles, are thought to contribute to the degradation of the wiring in brain cells and lead to the symptoms of Alzheimer's disease.
Neurofibrillary tangles, insoluble twisted fibers that build up inside neurons, are like power lines getting crossed up and sending energy to the wrong location.
 
 
 
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