NEMO


Also found in: Legal, Financial, Acronyms, Wikipedia.

NEMO

NF-kB Essential Modulator. A regulatory sub-unit of the inhibitor of NF-kappaB kinase (IKK) complex encoded by IKBKG on chromosome Xq28,  which activates NF-kappaB, triggering activation of genes involved in inflammation, immunity, cell survival, and other pathways. NEMO has an antiapoptotic function independent of its role in the IKK pathway, which prevents receptor-interacting protein-1 (RIP1) from engaging caspase-8 before IKK-mediated induction of antiapoptotic genes. Without NEMO, RIP1 associates with caspase-8, resulting in rapid TNF-induced apoptosis.
 
Abnormal in
IKBKG mutations are linked to incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several immunodeficiencies.
References in periodicals archive ?
Nemo Handy is the world's most widely used handheld air interface test tool providing customers with the best real-time measurement visualization on the handheld market.
Legion hit back with points from Donal Lyne - his shot tipped over by Nemo goalkeeper Micheal Martin - Moriarty and Conor Keane, but Nemo were never going to be denied.
Nemo Invex II is a mobile benchmarking, measurement, and optimization system combining powerful intuitive software and scalable hardware designed to create a superior benchmarking solution for wireless broadband networks.
The HiSilicon chipset locking functions bring a number of anticipated forcing features to Nemo Outdoor, enabling more accurate analysis and troubleshooting.
He takes over from Guy Thomas, who was chief executive of Nemo until he joined.
I don't mean to imply that my dogs don't love to give Nemo a chase around the house now and then because she eggs them on and teases them.
You moved onto the suburban drugdealing TV show Weeds shortly after Nemo came out - what was it like making that jump?
While unofficially known as "Finding Nemo 2," Pixar's announcement of "Finding Dory" means there will be five upcoming films from the animation studio.
Wide rear sliding doors on each side of the Nemo make it easy for passengers to get in and out of as well as making any loading from the side simple once you have put the rear seatbacks down.
I would like to say thank-you to all who helped to get Nemo out of the horse trailer in which he was trapped, especially John Webster.
The tiny striped fish has one fin which is much smaller than the other, just like the star character in Pixdar's hit film Finding Nemo.
PERFORMER Natasha Engleby used to travel more than 300 miles a week to perfect her ice-skating skills in Coventry and is now travelling Britain as part of Disney's new Finding Nemo ice show.