NCK1

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NCK1

A gene on chromosome 3q21 that encodes an adapter protein which associates with tyrosine-phosphorylated growth factor receptors (e.g., KDR and PDGFRB) or their substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. It plays a role in DNA damage response by activating downstream effectors, such as that of CHEK2, and in ELK1-dependent
transcriptional activation in response to activated Ras signalling.
References in periodicals archive ?
Intent to out-migrate was measured by a destination country's request for verification of credentials submitted to the NCK.
Additionally, the NCK did not record requests for verification from destination countries before the early 1990s.
A special thanks to the data clerks at the NCK, Peter Otieno Wauna, Enoch Barasa Wekesa, George Aguya Shadrack, Gladys Njoki, and Dan Nashali, who worked tirelessly on data entry and cleaning and to Rankesh Willy in the DON, MoMS, for his assistance with nurse deployment data.
Since its inception, the NCK has routinely collected nursing data at the time of licensure and registration (Table 2).
As of 2006, NCK staff have been trained and are fully capable of routinely entering licensure and renewal information into the database, thereby ensuring system sustainability.
This number enables the NCK system to link with data collected from expansion to the worksites by the MOH, thereby providing more accurate information on local workforce dynamics.
In 2006, the project began linking the NCK workforce supply data with MOH worksites utilization data.
In addition, Nck affects pathways leading to cellular mitogenesis and morphogenesis (54).
A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.
The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events.
The companies were brought down by the failure of NCK Cranes, a recent acquisition which hit hard times and brought down the rest of the companies.
The problems facing Staffordshire Public Works have been caused, in the main, by the acquisition of NCK Cranes,' he said.