SCN10A

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SCN10A

A gene on chromosome 3p22.2 that encodes a voltage-gated sodium ion channel, which is an integral membrane glycoprotein. It is responsible for the initial rising phase of the action potential in most excitable cells.
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References in periodicals archive ?
Point mutations in homology domain II modify the sensitivity of rat Nav1.
Sangamo is using ZFP TFs to specifically repress the expression of three of these targets; the Vanilloid Receptor 1 (VR1), a non-selective cationic channel that responds to thermal, pH and capsacin stimulation; the Tyrosine kinase A receptor (TrkA), shown to be involved in chronic spinal cord injury, and the sodium channel Nav1.
Vice President Biology, will deliver a presentation entitled "The Role of Nav1.
present the first report of a subtype selective Nav1.
Josephine Lai from the University of Arizona presented a poster titled "Small interfering RNA targeting NaV1.
CAMBRIDGE, England -- Ionix Pharmaceuticals, a leader in the discovery and development of analgesic drugs, today announced that it has been granted further patent protection in support of its programmes to develop analgesics that modulate the sodium channel drug target, Nav1.
Ionix also owns granted patents in the United States and Europe relating to the Nav1.
These patents originate from pioneering work on the discovery and validation of Nav1.
Our patent estate on this drug target strengthens our leadership in the search for proprietary Nav1.