National Polyp Study

National Polyp Study

GI disease A 10-year study that found that colonoscopy was more effective than barium enema in detecting precancerous adenomas, reported in June 2000, NEJM.
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In contrast, data from the influential National Polyp Study assessed screening colonoscopy in high-risk patients who first underwent polypectomy (N.
PHILADELPHIA -- The first colonoscopy done on a person has the greatest impact for preventing death from colorectal cancer, and subsequent surveillance colonoscopies play a lesser role, based on a new analysis of 20-year follow-up data collected in the National Polyp Study.
In earlier reports, researchers from the National Polyp Study showed that patients with three or more adenomas at baseline have an increased risk of subsequent advanced adenomas or colorectal cancer.
Proof of this principle was provided by the National Polyp Study, which established that colonoscopic polypectomy can dramatically reduce the incidence of colorectal cancer.
Prevention of colorectal cancer by colonoscopic polypectomy: the National Polyp Study Workgroup.
For the past ten years, the Sloan-Kettering Cancer Center in New York has conducted the National Polyp Study with six other hospitals.
The investigators performed long-term follow-up of subjects who had participated in the National Polyp Study, a randomized clinical trial of patients prospectively referred to seven clinical centers for colonoscopy during 19801990.
The investigators also compared colorectal cancer mortality in the study cohort against that in a group of 773 National Polyp Study participants who had been found to have nonadenomatous polyps on their initial colonoscopy.
5,9) Indeed, the National Polyp Study revealed that polypectomy reduced the incidence of colorectal cancer by 76 to 90%.
Preliminary data from the National Polyp Study were reported by Winawer et al[35] during the Digestive Disease Week in May of 1991 in New Orleans.
Two-thirds of patients found to have an adenoma at initial colonoscopy are at low risk for recurrence and do not need follow-up surveillance colonoscopy at 3 years, new data from the National Polyp Study indicate.

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