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(naff-ti-feen) ,


(trade name)


Therapeutic: antifungals
Pregnancy Category: B


Treatment of a variety of cutaneous fungal infections, including tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea corporis (ringworm).


Affects the synthesis of the fungal cell wall.

Therapeutic effects

Decrease in symptoms of fungal infection.


Absorption: Absorption through intact skin is minimal.
Distribution: Distribution after topical administration is primarily local.
Metabolism and Excretion: Systemic metabolism and excretion not known following local application.
Half-life: Not applicable.

Time/action profile



Contraindicated in: Hypersensitivity to active ingredients, additives, preservatives, or bases; Contains alcohol and should be avoided in patients with known intolerance.
Use Cautiously in: Nail and scalp infections (may require additional systemic therapy); Obstetric / Lactation: Safety not established.

Adverse Reactions/Side Effects


  • burning
  • dryness
  • itching
  • local hypersensitivity reactions
  • redness
  • stinging


Drug-Drug interaction

Not known.


Topical (Adults) Apply cream once daily for 2 wk. Apply gel twice daily for up to 4 wk.


Cream: 2%
Gel: 1%

Nursing implications

Nursing assessment

  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Indications)


  • Consult health care professional for proper cleansing technique before applying medication.
  • Topical: Apply small amount to cover affected area completely. Avoid the use of occlusive wrappings or dressings unless directed by health care professional.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes and vaginal area.
  • Caution patient that some products may stain fabric, skin, or hair. Check label information. Fabrics stained from cream can usually be cleaned by handwashing with soap and warm water.
  • Patients with athlete’s foot should be taught to wear well-fitting, ventilated shoes, to wash affected areas thoroughly, and to change shoes and socks at least once a day.
  • Advise patient to report increased skin irritation or lack of response to therapy to health care professional.

Evaluation/Desired Outcomes

  • Decrease in skin irritation and resolution of infection. Early relief of symptoms may be seen in 2–3 days.


/naf·ti·fine/ (naf´tĭ-fēn) a broad-spectrum antifungal agent, used topically as the hydrochloride salt.


an antifungal drug in the allylamine class, closely related to terbinafine.
References in periodicals archive ?
Naftin effectively treats tinea infections that are responsible for athlete's foot, jock itch and ringworm.
Merz also offers Naftin, the most frequently prescribed branded topical antifungal treatment.
Merz expanded into other areas of therapeutic skin care in 1999 with the acquisition of Naftin topical antifungal and Aqua Glycolic, an alpha-hydroxyacid-based line.
As expected, the podiatrists were very interested in Naftin, the premiere prescription antifungal treatment for tinea that we recently acquired from Allergan Inc.