NSAIDs


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NSAIDs

Abbreviation for nonsteroidal antiinflammatory drugs , under drug; for example, aspirin, ibuprofen.

NSAIDs

Abbrev. for NON-STEROIDAL ANTI-INFLAMMATORY DRUGS.

NSAIDs

This abbreviation stands for non-steroidal anti-inflammatory drugs, which are medications such as Ibufprofen that are used to control pain and inflammation. Most may be purchased over the counter. One of their major side effects is that they decrease the effect of the normal blood clotting factors in blood. In patients undergoing surgical or endoscopic procedures, this can lead to an increased risk of bleeding.

non-steroidal anti-inflammatory drugs

; NSAIDs group of anti-inflammatory and analgesic drugs that include aspirin, propionic acid derivatives (e.g. ibuprofen, fenbrufen, ketoprofen) and similar drugs (e.g. diclofenac, difusinal, etodolac, indometacin, meloxicam, prioxicam, sulindac, ketorolac and mefenamic acid); action: NSAIDs suppress inflammation and pain by inhibiting the cyclooxygenase pathway and preventing release of inflammatory mediators (e.g. prostacyclins, prostaglandins and thromboxanes); used to control acute inflammation and pain (e.g. soft-tissue or bone injury), chronic inflammation (e.g. associated with osteo- or rheumatoid arthritis); side-effects of long-term use include reduced healing, compromised immunity, increased susceptibility to infections, epidermal atrophy (thinning of skin), peripheral oedema, bruising and bleeding tendency (i.e. antiplatelet effect), gastric irritation and/or ulceration, tinnitus and anaemia (secondary to gastrointestinal bleeding) (Table 1); NSAIDs are contraindicated in ischaemic heart disease, cerebrovascular disease, peripheral arterial disease and heart failure; patients with angina or ischaemic heart disease, or those at risk of cerebrovascular accident (stroke) are advised to take 75mg aspirin daily; NSAIDs alone may be inadequate to control postoperative pain (see Table 2)
Table 1: The range of side-effects of long-term non-steroidal anti- inflammatory drug (NSAID) medication
SystemEffect
GastrointestinalNausea; dyspepsia; diarrhoea; peptic ulceration or perforation; bleeding
RenalFluid retention; peripheral oedema; renal failure; papillary necrosis; interstitial fibrosis
RespiratoryBronchoconstriction; pulmonary eosinophilia; alveolitis
CoagulationReduced platelet aggregation; increased bleeding time; easy bruising
SkinSevere allergic reactions (e.g. Stevens-Johnson syndrome); toxic epidermal necrolysis; angioedema; skin thinning; reduced healing
VisceralCongestive heart failure; hepatitis; pancreatitis; aseptic meningitis
Table 2: The range of side-effects of long-term non-steroidal anti- inflammatory drug (NSAID) medication
SystemEffect
GastrointestinalNausea; dyspepsia; diarrhoea; peptic ulceration or perforation; bleeding
RenalFluid retention; peripheral oedema; renal failure; papillary necrosis; interstitial fibrosis
RespiratoryBronchoconstriction; pulmonary eosinophilia; alveolitis
CoagulationReduced platelet aggregation; increased bleeding time; easy bruising
SkinSevere allergic reactions (e.g. Stevens-Johnson syndrome); toxic epidermal necrolysis; angioedema; skin thinning; reduced healing
VisceralCongestive heart failure; hepatitis; pancreatitis; aseptic meningitis

NSAIDs

Abbreviation for nonsteroidal antiinflammatory drugs.

NSAIDs,

n.pl the acronym for nonsteroidal antiinflammatory drugs. See also naproxen.

NSAIDs

Patient discussion about NSAIDs

Q. Is there any good source for heel pain relief, besides NSAIDs? My heel pain is most severe at night when I sleep. It's as if the way I position my feet worsen the condition, but I'm at a loss to know how to position my feet. During the day my heels feel so but don't typically bother me.

A. I have found that keeping my feet flexed (the position they are in when standing) helps ease the pain of plantar facitis. I also don't let my feet get cold(wear socks)and keep heavy blankets and quilts off the feet. Placing a box under the covers at the foot of the bed will help keep the blankets up. Do try the exercises recommended on the above web sites. It usually resolves in about 6 months. Best wishes!

More discussions about NSAIDs
References in periodicals archive ?
But they added: "We documented that current use of all studied NSAIDs, including naproxen, was associated with an increased risk.
In an editorial accompanying the study, two Danish health researchers said the fact they can be bought in supermarkets "further fuels the common misconception that NSAIDs are safe for everyone", they said.
In the study, the researchers have gathered all research on the use of NSAIDs in patients with heart disease.
Physicians should exercise caution when administering NSAIDs to people with hypertension and closely monitor renal function," said senior study author Hui-Ju Tsai.
If they have a history of bleeding or must take blood thinners, I recommend completely against taking NSAIDs," explains Dr.
In a rheumatology clinic in the West Midlands, UK, an audit on the use of cyclooxygenase-2 (COX-2) selective NSAIDs found that 92% of patients who were taking NSAIDs should have been prescribed a COX-2-selective agent in accordance with NICE guidelines.
In a drug safety communication, the agency did not provide the exact language that will be used on NSAID labels, but said that they "will be revised to reflect" information describing that:
All of the NSAIDs studied, including naproxen, roughly doubled the risk of being hospitalized because of congestive heart failure.
NSAIDs were the most commonly reported analgesics used at both races.
The demonstration of two unique isoforms of cyclooxygenase (designated as COX-1 and COX-2) has led to a greater understanding of the mechanisms of action of NSAIDs and their toxicity (3).
NSAIDs are commonly used and are associated with increased cardiovascular risk in people with heart disease or those at high risk.