NOS3


Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
Related to NOS3: nose

NOS3

A gene on chromosome 7q36 that encodes endothelial nitric oxide synthase (eNOS), a small molecule implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. eNOS is a critical mediator of cardiovascular homeostasis that regulates the diameter of blood vessels and keeps vascular proliferation and apoptosis in check. It is upregulated by dynamin, porin and soluble guanylyl cyclase, and downregulated by interactions with Hsp90 and Cav-1 in the Golgi and by NOSIP and NOSTRIN at the plasma membrane. NOS3 is also a less preferred gene symbol for what is now designated as NANOS3, see there.
Mentioned in ?
References in periodicals archive ?
In conclusion, the SNPs ACE rs4341 and NOS3 rs1799983 were significantly associated with blood pressure in a dose response model in Pakistani subjects under study.
Genetic etiology of coronary artery disease considering NOS3 gene variant rs1799983.
The NOS3 rs2853792 AG/GG genotype and the SOD2 rs5746088 GA/AA genotype were negatively associated with CVD and CHD after FDR adjustment.
Among the SNPs that were tested, NOS3 rs2853792, SOD2 rs5746088, and MTHFR rs1801133 were significantly associated with CVD in this population.
In the present study, though intron 4a/b polymorphism of NOS3 had no association with essential hypertension, a trend toward a higher frequency of the a allele was apparent among the patients' group.
A random sample (n = 738) was successfully genotyped for variants at the NOS3 locus.
In the present study we used the National Cholesterol Education Program Adult Treatment Panel III definition of metabolic syndrome, recently modified (25) for analysis of the association between NOS3 haplotypes and metabolic syndrome in a population-based study.
Among the mechanisms that may be responsible for NOS3 uncoupling, tetrahydrobiopterin (BH4, a fundamental cofactor of NOS) deficiency has been often described [71-73].
In general, the non-CpG island loci in NOS1, NOS2A, and NOS3 were methylated > 75%.
5] was also positively associated with percent DNA methylation in both positions measured in NOS3.
Several lines of evidence indicate a significant association between mutations of the NOS3 gene and cardiovascular disease (10,11), with discrepant findings possibly related to racial differences (12,13).
Tenders are invited for for Supply of Medicine, Inj Fosaprepitant 150 mg 5 NOS2 Inj Cisplatin 50mg 10 NOS3 Inj 5 Fluorouracil 500Mg 30 NOS1 Inj Albumin bound Paclitaxel etc.