NOS2


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NOS2

A gene on chromosome 17q11.2-q12 that encodes inducible nitric oxide synthase (iNOS), a small molecule that has various roles in cellular functions and acts via a cGMP-mediated signal transduction pathway. iNOS is both tumouricidal and bactericidal, has nitrosylase activity, and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. It is regulated by calcium/calmodulin, induced by endotoxins and cytokines, including IFN-gamma, in synergy with bacterial lipopolysaccharides (LPS, TNF or IL1B/IL-1 beta). Aspirin inhibits its expression and function. Some genetic variants of NOS2 play a role in resistance to malaria. NOS2 is also a less preferred gene symbol for what is now designated as NANOS2, see there.
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NOS2 Expression Correlates with Lymph Node Metastasis in SCC.
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.
The increased concentrations of exhaled NO in asthma originate predominately in the lower airway (36) and are most likely attributable to activation of NOS2 by damage to airway epithelial cells and by inflammation (37, 38), with a small contribution from NOS1 (39).
Tenders are invited for for Supply of Medicine, Inj Fosaprepitant 150 mg 5 NOS2 Inj Cisplatin 50mg 10 NOS3 Inj 5 Fluorouracil 500Mg 30 NOS1 Inj Albumin bound Paclitaxel etc.