NMDA receptor


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Related to NMDA receptor: AMPA receptor, NMDA receptor antagonist

NMDA re·cep·tor

a type of glutamate receptor that participates in excitatory neurotransmission and also binds N-methyl-d-aspartate; may be particularly involved in the cell damage observed in individuals with Huntington disease.

NMDA receptor

(ĕn′ĕm′dē′ā′)
n.
A brain receptor activated by glutamate, which when excessively stimulated may cause cognitive defects in Alzheimer's disease.
References in periodicals archive ?
The company has a proven platform for discovery of novel compounds that work through a unique mechanism to modulate -- rather than block or over-activate -- NMDA receptors and enhance synaptic plasticity, the foundation of neural cell communication.
Quoin's proposed second product, QRX002, will be a once-daily transdermal NMDA receptor antagonist for the treatment of suicidal ideation in military veterans with PTSD.
25-27] Peripheral injection of NMDA receptor antagonist attenuates pain associated with neuropathic or inflammatory origin.
Overactivity or underactivity of the GLU NMDA receptor has emerged as scientifically plausible mechanisms underlying psychotic and mood disorders.
Nonetheless, these syndromes highlight the importance of NMDA receptor signaling for the genesis of symptoms associated with psychotic disorders.
MK-801, which is an NMDA receptor antagonist, was administered intraperitoneally twice a day (at 9:00h and 16:00h) at a dose of 0.
Ketamine, a non-competitive antagonist of NMDA receptor can prevent the induction of central sensitization caused by stimulation of peripheral nociceptor as well as helps in blocking the wind-up phenomena.
The areas of the brain affected by the encephalitis, including limbic and forebrain structures, express the NMDA receptor.
Ketamine then blocks NMDA receptor, glutamate mediated, nociceptive signals (Weinbroum, 2012).
Effects of a specific NMDAR agonist NMDA, a noncompetitive NMDA receptor antagonist MK801 and a selective antagonist of NMDA receptors containing the NR2B subunit ifenprodil on the antinociception of i.
Mnemosyne is developing a new class of molecules, Subunit Selective NMDA Receptor Modulators (SNRMs) for the neuropsychiatry market.
NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory.