Rapastinel (GLYX-13), an allosteric NMDA receptor
modulator, exerts its antidepressant effects by acting at a novel NMDA receptor
The role that central sensitization and the NMDA receptor
have in pathological pain is highlighted by studies that show blocking of central sensitization with NMDA antagonists abolishes pain hypersensitivity in patients with neuropathic pain.
The Subunit-selective NMDA Receptor
Modulators being developed by Mnemosyne presents an innovative strategy for developing new drugs for neuropsychiatric diseases and we look forward to working with the Mnemosyne team to bring these new candidates to the clinic, said Peter Barrett, Partner, Atlas Venture.
The multi-target program agreement will be enabled by the expertise of Mnemosyne in NMDA receptor
pharmacologyand supportedby Jubilant's translational center in Malvern, Pennsylvania and byscientists from Jubilant's India based facilities.
Because these receptors are so similar in structure, it was assumed that they function in much the same way, but when we altered the dimer interface, the site where two subunits come together within each pair, we found that the NMDA receptor
works just the opposite of the way that the AMPA receptor works," points out Popescu.
2004b, NMDA receptor
function, neuroplasticity, and the pathophysiology of schizophenia.
Since compounds that inhibit the NMDA receptor
thwart fear extinction, Davis reasoned that compounds that facilitate the protein's response would speed it.
Overstimulation of the N-methyl-Dasparatate (NMDA) receptors has been implicated in AD; an NMDA receptor
antagonist such as memantine may serve as a suitable treatment.
Memantine (1-amino-3,5-dimethyladamantane) is a low-affinity, noncompetitive NMDA receptor
The topics include studies of noncompetitive NMDA receptor
antagonists, systemically active antagonists at the NMDA glycine site, AMPA and NMDA antagonists that are active in vivo, antagonists of group I metabotropic glutamate receptors, and AMPA antagonists for therapy of stroke and trauma.
Research indicates that NMDA receptor
antagonists have the potential to prevent the injury and death of neurons related to a variety of conditions, including neuropathic pain, Alzheimer's disease, Huntington's disease, and AIDS-related dementia.
The gene NR2B is part of a brain cell receptor called the NMDA receptor