NMDA antagonist

NMDA antagonist

Neurology Any of a number of agents that protect against brain damage in neurologic disorders–eg, stroke; PCP–phencyclidine and ketamine are effective, but have psychotomimetic effects or damage neurons in the cerebral cortex; diazepam and barbiturates act at the GABA receptor channel complex, and may prevent the unwanted side effects of NMDA antagonists
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Ketamine is an NMDA antagonist and it can potentially be used for the management of refractory status epilepticus (RSE).
M2 PHARMA-January 23, 2018-Biohaven Receives FDA Approval to Begin Clinical Investigation of Novel Low-Trapping NMDA Antagonist
Memantine is another conventional nonselective NMDA antagonist used for the treatment of dementia.
The GLU hypothesis of schizophrenia (4) grew out of the observation that phencyclidine, a drug of abuse that is a potent NMDA antagonist (50-fold stronger than ketamine), can trigger in healthy individuals a severe psychosis indistinguishable from schizophrenia, with positive and negative symptoms, cognitive impairment, thought disorder, catatonia, and agitation.
Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration.
Enhancement of paired-pulse depression in the dentate gyrus in vivo by the NMDA antagonist, MK-801, and electrical kindling.
27] This antihyperalgesic property of NMDA antagonist is consistent with the overall VAS pattern in the study which showed significant decrease in VAS score in the magnesium group than the placebo group during whole observation period.
The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive NMDA antagonist in active avoidance and lever-press learning in mice.
27) Therefore, it can be suggested that the NMDA antagonist activity of Guaifenesin may contribute to its anticonvulsant activity seen in this study.
We demonstrated that central delivery of the NMDA antagonist MK-801 disrupted the acquisition of preferences for a grape flavor paired with a carbohydrate (polycose) in hungry rats.
NR2B subunit specific NMDA antagonist Ro25-6981 inhibits the expression of conditioned fear: a comparison with the NMDA antagonist MK801 and fluoxetine.
The formation of a new gustatory memory trace in rats is prevented by the non-competitive NMDA antagonist ketamine.