NLRP6

NLRP6

A gene located on chromosome 11p15 that encodes a cytoplasmic protein of the NALP protein family, which is thought to activate CASP1 and promote activation of NF-kappa-B.
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We recently identified the NLRP6 inflammasome as a critical innate immune regulator of colonic microbial ecology, with its disruption resulting in auto-inflammation and tumorigenesis.
actinomycetemcomitans up regulates NLRP3, IL 1[beta] and down regulates NLRP6 in peripheral mononuclear leukocytes.
A latest study showed that NLRP6 shaped the characteristic of intestinal flora and that the loss of NLRP6 induced more colitogenic microbiota to flourish (Elinav et al.
Recientemente se han propuesto dos nuevos inflamasomas, denominados NLRP6 y NLRP12, aunque su funcionalidad como tales aun requiere estudio (15-17).