NLRP6

NLRP6

A gene located on chromosome 11p15 that encodes a cytoplasmic protein of the NALP protein family, which is thought to activate CASP1 and promote activation of NF-kappa-B.
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A latest study showed that NLRP6 shaped the characteristic of intestinal flora and that the loss of NLRP6 induced more colitogenic microbiota to flourish (Elinav et al.
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.
NLRP6 belongs to a family of proteins that are part of the innate immune response that serves as the first line of defense.
Surprisingly, mice without NLRP6 were far more likely to survive infection with lethal doses of the bacteria than their normal counterparts.
Researchers went on to show that NLRP6 suppressed activity in pathways that trigger production of proteins called cytokines, which promote inflammation to combat the infection.