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Investigators showed that the protein NLRP12 works in T cells to limit production of chemical messengers or cytokines that fuel inflammation.
Understanding the precise inner-workings of NLRP12 in T cells will help guide efforts to develop therapies to ease symptoms by taming inflammation driven by T cells.
Previous research from Kanneganti's laboratory showed that rather than fueling production of the cytokines that drive inflammation, NLRP12 played a different role in the innate immune response.
The latest study showed that NLRP12 serves the same anti-inflammatory function in T cells.
This study provides the first evidence that NLRP12 can function in adaptive immune cells to regulate inflammation and impact various autoimmune disorders," Kanneganti said.
Investigators linked the new symptoms to increased IL-4 production by T cells that lacked NLRP12.
Recently, an increasing number of papers concerning human inflammatory diseases have focused on NLRP12, a member of the NLR gene family.
NLRP12 acts as negative regulator of inflammation, and this function requires the assistance of ASC (apoptotic speck protein) (Wang et al.
NLRP12 is a checkpoint in the process of many inflammatory diseases.
In this study, we performed the case-control study to explore the association between NLRP12 polymorphisms and NSDD in New Zealand White rabbits.
NLRP12 mRNA expression and association with NSDD were subsequently investigated.
A total of 24 unrelated rabbits were randomly selected from both case and control groups for mutational analysis by sequencing the genomic region encompassing the entire NLRP12 gene.
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