NLGN3

NLGN3

A gene on chromosome Xq13.1 that encodes neuroligin 3, a neuronal cell surface protein involved in cell–cell interactions, which forms intercellular junctions by binding to beta-neurexins. It may play role in forming or maintaining synaptic junctions, as well as glia–glia or glia–neuron interactions in the developing peripheral nervous system.
 
Molecular pathology
Defects of NLGN3 have been linked to an increased susceptibility to Asperger syndrome (X-linked type 1) and to autism (X-linked type 1).
References in periodicals archive ?
Rat models lacking functional NLGN3 and FMR1 genes also display other unexpected characteristics, including compulsive chewing on water bottles and wood blocks.
Currently SAGE Labs publicly provides two rat lines with knockouts of autism-associated FMR1 and NLGN3 genes.
Mutations of the x-linked genes encoding neurologins NLGN3 and NLGN4 are associated with autism.